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Invitrogen
Ephrin B3 Monoclonal Antibody (88838)
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Product Details
MA5-61364
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
88838
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Ephrin-B3, Leu28-Ser224
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
500 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EPH-related receptor transmembrane ligand ELK-L3; EPH-related receptor tyrosine kinase ligand 8; Ephrin-B3; LERK-8; unnamed protein product
Gene Aliases: EFL6; EFNB3; EPLG8; LERK8
UniProt ID: (Human) Q15768
Entrez Gene ID: (Human) 1949
cell-cell signaling
nervous system development
axon guidance
adult walking behavior
axon choice point recognition
cell differentiation
T cell costimulation
viral entry into host cell
ephrin receptor signaling pathway
negative regulation of axonogenesis
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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