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Invitrogen
LAMTOR3 Monoclonal Antibody (448406)
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Product Details
MA5-61430
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
448406
Immunogen
E. coli-derived recombinant human MP1, Ala2-Ser124
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; MAPK scaffold protein 1; Mek; MEK binding partner 1; MEK partner 1; MEK-binding partner 1; mitogen activated protein, binding protein; mitogen-activated protein kinase kinase 1 interacting protein 1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1; Mp1; Ragulator complex protein LAMTOR3; unnamed protein product
Gene Aliases: AW556229; LAMTOR3; MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633; PRO2783; Ragulator3
UniProt ID: (Human) Q9UHA4, (Rat) Q5U204, (Mouse) O88653
Entrez Gene ID: (Human) 8649, (Rat) 362045, (Mouse) 56692
protein localization
regulation of TOR signaling
positive regulation of TOR signaling
TORC1 signaling
positive regulation of MAPK cascade
cellular response to amino acid stimulus
protein localization to cell junction
positive regulation of intracellular signal transduction
positive regulation of TORC1 signaling
activation of MAPKK activity
cellular protein localization
positive regulation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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