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Invitrogen
HHV-8 ORF74 Monoclonal Antibody (462510)
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Product Details
MA5-61536
Product Specifications
Species Reactivity
Virus
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
462510
Immunogen
NS0 mouse myeloma cell line transfected with viral HHV8-ORF74, Met1-Thr342
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
HHV-8 ORF74 is a gene encoded by Human Herpesvirus 8 (HHV-8), also known as Kaposi's Sarcoma-associated Herpesvirus (KSHV). ORF74 is notable for encoding a G protein-coupled receptor (GPCR) known as vGPCR or KSHV-GPCR. This viral GPCR is homologous to human chemokine receptors and is constitutively active, meaning it can signal in the absence of ligand binding. The constitutive activity of ORF74 leads to the continuous activation of downstream signaling pathways, including those involving MAPK/ERK and NF-kappaB, which promote cell proliferation, survival, and angiogenesis. This activity is implicated in the pathogenesis of Kaposi's Sarcoma, as well as other HHV-8-associated diseases such as primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). The oncogenic potential of ORF74 makes it a significant target for research into therapeutic interventions aimed at treating HHV-8-related malignancies. Understanding the mechanisms by which ORF74 contributes to viral oncogenesis and immune evasion is critical for the development of targeted therapies that can mitigate the effects of this viral gene product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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