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Invitrogen
IL1R2 Monoclonal Antibody (130817)
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Product Details
MA5-61576
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
130817
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse IL-1 RII, Phe14-Glu355 (predicted)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
500 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD121 antigen-like family member B; IL-1 receptor beta chain; IL-1 type II receptor; IL-1R-2; IL-1R-beta; IL-1RT-2; IL-1RT2; Il1r2; ILR2; interleukin-1 receptor beta; unnamed protein product
Gene Aliases: CD121b; Il1r-2
UniProt ID: (Mouse) P27931
Entrez Gene ID: (Mouse) 16178
cell surface receptor signaling pathway
negative regulation of protein processing
cytokine-mediated signaling pathway
negative regulation of interleukin-1 alpha production
negative regulation of cytokine production involved in inflammatory response
negative regulation of interleukin-1-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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