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Invitrogen
VAMP1/VAMP2 Monoclonal Antibody (540524)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-61608
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
540524
Immunogen
E. coli-derived recombinant human VAMP-1, Met1-Lys96
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis. VAMP (also know as synaptobrevin) is part of the synaptic vesicle docking and fusion complex and plays a central role in neuroexocytosis. Two VAMP (vesicle-associated membrane protein) isoforms are expressed in the nervous system and are differently distributed among the specialized parts of the tissue. VAMP-1 and -2 are present in all tissues tested, including kidney, adrenal gland, liver, pancreas, thyroid, heart, and smooth muscle. The two isoforms are differentially expressed in various tissues and their level may depend on differentiation. VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy. Evidence for the importance of neuronal VAMPproteins in the physiology of all cells is indicated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: spastic ataxia 1 (autosomal dominant); synaptobrevin 2; synaptobrevin II; synaptobrevin-1; synaptobrevin-2; unnamed protein product; VAMP1; vesicle targeting/fusion protein; vesicle-associated membrane 2; vesicle-associated membrane protein 1 (synaptobrevin 1)
Gene Aliases: CMS25; lew; NEDHAHM; SAX1; SPAX1; Syb-1; Syb-2; SYB1; SYB2; sybII; VAMP-1; VAMP-2
UniProt ID: (Human) P23763, (Human) P63027, (Mouse) Q62442, (Mouse) P63044
Entrez Gene ID: (Human) 6843, (Human) 6844, (Mouse) 22317, (Mouse) 22318
vesicle fusion
neurotransmitter secretion
vesicle-mediated transport
SNARE complex assembly
exocytosis
response to glucose
protein transport
synaptic vesicle exocytosis
calcium ion regulated exocytosis
regulation of exocytosis
cellular response to insulin stimulus
Golgi to plasma membrane protein transport
eosinophil degranulation
neutrophil degranulation
natural killer cell degranulation
synaptic vesicle endocytosis
long-term synaptic potentiation
regulation of vesicle-mediated transport
membrane fusion
protein-containing complex assembly
mucus secretion
positive regulation of intracellular protein transport
regulation of delayed rectifier potassium channel activity
regulation of histamine secretion by mast cell
regulation of calcium ion-dependent exocytosis
regulated exocytosis
hormone secretion
response to cholesterol
clathrin-mediated endocytosis
exocytic insertion of neurotransmitter receptor to postsynaptic membrane
regulation of synaptic vesicle recycling
synaptic vesicle priming
regulation of synaptic vesicle fusion to presynaptic membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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