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Invitrogen
C. botulinum BoNT-D Heavy Chain Monoclonal Antibody (682810)
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Product Details
MA5-61696
Product Specifications
Species Reactivity
Bacteria
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
682810
Immunogen
E. coli-derived recombinant Clostridium botulinum Neurotoxin Type D Heavy Chain, Asn862-Glu1276
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
The BoNT-D Heavy Chain is a crucial component of botulinum neurotoxin type D (BoNT-D), which is produced by Clostridium botulinum, a gram-positive, spore-forming bacterium known for causing botulism. BoNT-D is one of the seven serotypes of botulinum toxin, each of which is highly potent and capable of causing severe paralytic illness. The heavy chain of BoNT-D plays a vital role in the neurotoxin's mechanism of action. It is responsible for binding to specific receptors on the surface of nerve cells and facilitating the internalization of the toxin into the cell. Once inside, the heavy chain aids in the translocation of the light chain into the cytoplasm, where the light chain exerts its enzymatic activity by cleaving SNARE proteins, thereby inhibiting neurotransmitter release and leading to flaccid paralysis. Understanding the structure and function of the BoNT-D heavy chain is essential for the development of antitoxins and therapeutic interventions. This knowledge is also crucial for advancing medical applications of botulinum toxins in treating conditions such as muscle spasticity, chronic pain, and other disorders related to neurotransmission. Research into the heavy chain of BoNT-D not only helps in managing botulism but also expands the potential therapeutic uses of botulinum toxins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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