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Invitrogen
UBB (mutant) Monoclonal Antibody (83456)
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Product Details
MA5-61756
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
83456
Immunogen
E. coli-derived recombinant human Ubiquitin+1, Met1-Gly75, YADLREDPDRQDHHPGSGAQ (C-terminal sequence generated by a frameshift)
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
500 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
UBB (ubiquitin B) is a gene that encodes ubiquitin, a small regulatory protein that is ubiquitously expressed in eukaryotic cells. Ubiquitin plays a critical role in various cellular processes, including protein degradation, DNA repair, cell cycle regulation, and response to oxidative stress, by tagging proteins for degradation via the ubiquitin-proteasome system. Mutations in the UBB gene can lead to the production of defective ubiquitin proteins that can disrupt these essential cellular processes. One notable mutant form, UBB+1, is produced through a molecular process called frameshift mutation, which can occur during transcription. This mutant ubiquitin acts as a proteasome inhibitor rather than a substrate, leading to the accumulation of misfolded or damaged proteins. Such accumulation is associated with neurodegenerative diseases, including Alzheimer's disease and other forms of dementia, where impaired protein degradation contributes to disease pathology. Understanding the impact of UBB mutations, particularly UBB+1, is crucial for developing therapeutic strategies aimed at enhancing proteasome function and mitigating the effects of protein aggregation in neurodegenerative disorders. Research into UBB mutants also provides broader insights into the mechanisms of protein homeostasis and the potential for targeting the ubiquitin-proteasome system in various diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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