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Invitrogen
DTX1/DTX4 Monoclonal Antibody (730612)
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Additional Information:
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-61770
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
730612
Immunogen
E. coli-derived recombinant human DTX1/DTX4, Met1-Phe147
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
DTX1 (Deltex 1) and DTX4 (Deltex 4) are genes that encode members of the Deltex family of E3 ubiquitin ligases, which play crucial roles in the regulation of the Notch signaling pathway. Notch signaling is a highly conserved cellular communication system that is fundamental to cell differentiation, proliferation, and apoptosis. DTX1 and DTX4 function by tagging specific proteins with ubiquitin, marking them for degradation by the proteasome, thereby modulating the intensity and duration of Notch signaling. These genes are involved in various developmental processes and have been implicated in the regulation of immune cell development, including T cells and B cells. Aberrations in the expression or function of DTX1 and DTX4 can lead to dysregulation of Notch signaling, which is associated with several pathological conditions such as cancer, particularly T-cell acute lymphoblastic leukemia, and other disorders involving abnormal cell growth and differentiation. Understanding the roles of DTX1 and DTX4 in Notch signaling and their broader biological functions is essential for developing targeted therapies aimed at correcting Notch pathway dysregulation in various diseases. Research into these genes offers insights into their potential as therapeutic targets and biomarkers for disease diagnosis and treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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