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Invitrogen
Bcl-W Monoclonal Antibody (90316)
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Product Details
MA5-61930
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
90316
Immunogen
E. coli-derived recombinant human Bcl-w, Met1-Thr172
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Using a PCR-based strategy, an additional protein with life-promoting activity, designated Bcl-w, has been identified. The protein is highly conserved between mouse and human and is encoded by a gene located near the TCRalpha gene on chromosome 14. Bcl-w is expressed in myeloid cell lines but not in T and B lymphocytes, and can be found in a wide range of tissues. An alternative splicing event in exon 4 results in two transcripts. The first, Bcl-w, encodes a protein of 193 amino acids, and the second, Bcl-w/rox, encodes a protein 333 amino acids in length. The "rox" portion of Bcl-w/rox shows a striking 66% amino acid sequence identity with the Drosophila rox2 protein; however, the Bcl-w/rox transcript may be expressed at very low levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis regulator Bcl-W; Bcl-2-like protein 2; Bcl2-L-2; BCL2-like 2 protein; Bcl2-like protein 2; KIAA0271; protein phosphatase 1, regulatory subunit 51; unnamed protein product
Gene Aliases: BCL-W; BCL2-L-2; BCL2L2; BCLW; KIAA0271; PPP1R51
UniProt ID: (Human) Q92843
Entrez Gene ID: (Human) 599
release of cytochrome c from mitochondria
developmental process involved in reproduction
apoptotic process
spermatogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
transmembrane transport
Sertoli cell proliferation
extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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