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Invitrogen
SLC19A1 Monoclonal Antibody (890513)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-61955
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
890513
Immunogen
NS0 mouse myeloma cell line transfected with human Reduced Folate Carrier/SLC19A1, Met1-Gln591
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclic dinucleotide:anion antiporter SLC19A1; folate transporter 1; folate:anion antiporter SLC19A1; intestinal folate carrier 1; placental folate transporter; reduced folate carrier 1; reduced folate carrier protein; reduced folate transporter 1; solute carrier family 19 (folate transporter), member 1; unnamed protein product
Gene Aliases: CHMD; FOLT; hRFC; hSLC19A1; IFC-1; IFC1; IMD114; MEGAF; REFC; RFC; RFC1; RFT-1
UniProt ID: (Human) P41440
Entrez Gene ID: (Human) 6573
protein binding
folic acid binding
folic acid transporter activity
reduced folate carrier activity
antiporter activity
methotrexate transporter activity
transmembrane transporter activity
xenobiotic transporter activity
cyclic-GMP-AMP binding
vitamin transmembrane transporter activity
cyclic-GMP-AMP transmembrane transporter activity
drug transmembrane transport
female pregnancy
response to xenobiotic stimulus
response to toxic substance
folic acid transport
folic acid metabolic process
vitamin transport
methotrexate transport
transmembrane transport
anion transmembrane transport
reduced folate transmembrane transport
cyclic-GMP-AMP transmembrane import across plasma membrane
positive regulation of cGAS/STING signaling pathway
transport across blood-brain barrier
folic acid import into cell
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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