Search
Invitrogen
NLRP6 Monoclonal Antibody (920631)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
MA5-61996
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
920631
Immunogen
E.coli-derived recombinant human NLRP6/NALP6, Lys35-Arg193
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Angiotensin II/vasopressin receptor; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PYPAF5; PYRIN-containing APAF1-like protein 5; unnamed protein product
Gene Aliases: AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; NLRP6; PAN3; PYPAF5
UniProt ID: (Human) P59044
Entrez Gene ID: (Human) 171389
immune system process
acute inflammatory response to antigenic stimulus
acute inflammatory response
negative regulation of inflammatory response to antigenic stimulus
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
protein secretion
response to bacterium
regulation of autophagy
negative regulation of interferon-gamma production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-18 production
negative regulation of toll-like receptor signaling pathway
interleukin-18-mediated signaling pathway
wound healing
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAPK cascade
innate immune response
host-mediated regulation of intestinal microbiota composition
regulation of inflammatory response
positive regulation of inflammatory response
negative regulation of immune response
defense response to Gram-positive bacterium
protein homooligomerization
protein maturation
defense response to virus
regulation of mucus secretion
necroptotic process
pyroptosis
negative regulation of ERK1 and ERK2 cascade
interleukin-1-mediated signaling pathway
neutrophil mediated killing of gram-positive bacterium
antiviral innate immune response
NLRP6 inflammasome complex assembly
positive regulation of interleukin-18-mediated signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support