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Invitrogen
Synapsin 1/2 Recombinant Rabbit Monoclonal Antibody (PSH10-29)
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FIGURE: 1 / 31
Synapsin 1/2 Antibody (MA562922) in ICC/IF
Immunofluorescence analysis of Synapsin 1/2 was performed using IMR-32 cells. The cells were fixed with 4% paraformaldehyde for 5 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Synapsin 1/2 Recombinant Rabbit Monoclonal Antibody (PSH10-29) (Product # MA562922) at 1:100 in 0.1% BSA, incubated at 4 degree celsiu... View More
Product Details
MA562922
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH10-29
Immunogen
Recombinant protein within human Synapsin I aa 1-705.
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control: Mouse brain tissue lysate, Rat brain tissue lysate, mouse primary neuronal, human brain tissue, mouse brain tissue, mouse retina tissue, rat brain tissue, rat retina tissue.
Tissue Specificity: Tissue enriched (brain)
Subcellular Location: Synapse, Golgi apparatus, Presynapse, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Sequence Similarities: 95% Mouse,Rat
Predicted band size: 62 kDa.
Target Information
The SYN1 gene, located on chromosome Xp11.3-p11.23, encodes synapsin I, a neuronal phosphoprotein critical for the regulation of synaptic vesicle release and neurotransmitter mediation. Synapsin I is involved in synaptic plasticity and the maintenance of synaptic vesicle pools, modulating neurotransmission and synaptic strength. The SYN2 gene, located on chromosome 3p25-p26, encodes synapsin II, another protein that plays a similar role in synaptic vesicle trafficking and neurotransmitter release. Both synapsin I and II are essential for proper neuronal function and are highly expressed in the brain. Dysregulations or mutations in these genes can be associated with neurological disorders such as epilepsy and schizophrenia, indicating their importance in maintaining the integrity of neural networks.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain protein 4.1; synapsin 1; synapsin 2; Synapsin I; synapsin Ib; Synapsin II; Synapsin-1; Synapsin-2; synaptic vesicle protein; truncated synapsin 1-S; unnamed protein product
Gene Aliases: 2900074L19Rik; AI836018; AI841723; EPILX; EPILX1; MRX50; Syn-1; SYN1; Syn1-S; SYN1a; SYN1b; SYN2; SYNI; SYNII
UniProt ID: (Human) P17600, (Human) Q92777, (Rat) P09951, (Mouse) O88935, (Mouse) Q64332, (Rat) Q63537
Entrez Gene ID: (Human) 6853, (Human) 6854, (Rat) 24949, (Mouse) 20964, (Mouse) 20965, (Rat) 29179
chemical synaptic transmission
neurotransmitter secretion
regulation of neurotransmitter secretion
neuron development
modulation of synaptic transmission
synapse organization
synaptic vesicle clustering
regulation of synaptic vesicle cycle
synaptic vesicle cycle
regulation of synaptic vesicle exocytosis
calcium ion regulated exocytosis
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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