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          • Primary Antibodies ›
          • Angiotensin I-VII Antibodies

          Invitrogen

          Angiotensin I-VII Monoclonal Antibody (A4)

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          Cite Angiotensin I-VII Monoclonal Antibody (A4)

          Additional Information:
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          • Antibody Testing Data (3)
          Angiotensin I-VII Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Angiotensin I-VII Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 3

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          Angiotensin I-VII Antibody (MA565967) in IHC (P)

          Immunohistochemistry analysis of Angiotensin I-VII in paraffin-embedded Human Liver cancer tissue. Samples were incubated with Angiotensin I-VII Monoclonal (Product # MA565967) antibody using a dilution of 40 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG (2 µg/mL) and DAB. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          Angiotensin I-VII Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Angiotensin I-VII Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Angiotensin I-VII Antibody in Western Blot (WB)
          Angiotensin I-VII Monoclonal Antibody (A4)

          Product Details

          MA565967

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.01-2 µg/mL
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          5-40 µg/mL
          -

          Immunocytochemistry (ICC/IF)

          5-20 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Rat

          Host/Isotype

          Mouse / IgG2a, lambda

          Class

          Monoclonal

          Type

          Antibody

          Clone

          A4

          Immunogen

          OVA Conjugated Angiotensin 1-7 (Ang1-7) (Asp34-Pro40)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          200 µg

          Purification

          Protein A/G

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.05% ProClin 300

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_3715115

          Target Information

          Angiotensin I through VII are bioactive peptides that form part of the reninangiotensin system (RAS), integral to regulating cardiovascular, renal, and fluid electrolytes. Angiotensin I, an inactive precursor, is converted into Angiotensin II, a potent vasoconstrictor, which in turn can be further processed into smaller peptides, such as Angiotensin III, IV, and Angiotensin(17). Angiotensin(17) is particularly noteworthy for its beneficial roles in countering the effects of Angiotensin II; it acts via the Mas receptor and is known for its protective effects against vascular aging. It reduces inflammation, oxidative stress, and modulates pathways related to prostaglandin, bradykinin, and nitric oxide. These peptides play diverse roles in maintaining blood pressure and hydroelectrolyte balance, alongside influencing cardiac and vascular functions. Research continues to elucidate the distinct physiological roles of each peptide, particularly the interplay between the traditional angiotensin pathways and the more recently understood actions mediated by angiotensin(17).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: ACE-related carboxypeptidase; ACE2; ACEH; alpha-1 antiproteinase, antitrypsin; Angiotensin 1-7; angiotensin I; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; Angiotensin I-VII; angiotensin II; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; Angiotensin-converting enzyme-related carboxypeptidase; Angiotensinogen; angiotensinogen (PAT); anigotensin-converting enzyme-related carboxypeptidase; fetal-liver predominant transporter 1; Metalloprotease MPROT15; peptidyl-dipeptidase A; pre-angiotensinogen; preangiotensinogen; renal angiotensin-converting enzyme 2; sACE2; N-terminally-truncated natural isoform; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8; unnamed protein product; zinc metalloprotease

          View more View less

          Gene Aliases: ACE2; ACEH; AGT; Ang; AngII; ANHU; ANRT; hFLT1; PAT; SERPINA8; UNQ868/PRO1885

          View more View less

          UniProt ID: (Human) Q9BYF1, (Human) P01019, (Rat) Q5EGZ1, (Rat) P01015

          View more View less

          Entrez Gene ID: (Human) 59272, (Human) 183, (Rat) 302668, (Rat) 24179

          View more View less

          Function(s)
          virus receptor activity endopeptidase activity carboxypeptidase activity metallocarboxypeptidase activity protein binding peptidase activity metallopeptidase activity peptidyl-dipeptidase activity zinc ion binding hydrolase activity identical protein binding metal ion binding transporter activator activity serine-type endopeptidase inhibitor activity hormone activity growth factor activity superoxide-generating NADPH oxidase activator activity sodium channel regulator activity type 1 angiotensin receptor binding type 2 angiotensin receptor binding receptor agonist activity glycoprotein binding angiotensin receptor binding metalloprotease protease inhibitor
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter regulation of cytokine production angiotensin maturation angiotensin-mediated drinking behavior regulation of systemic arterial blood pressure by renin-angiotensin proteolysis tryptophan transport viral life cycle receptor-mediated endocytosis of virus by host cell viral translation regulation of vasoconstriction regulation of cell proliferation ceramide biosynthetic process viral entry into host cell receptor-mediated virion attachment to host cell negative regulation of smooth muscle cell proliferation regulation of inflammatory response positive regulation of amino acid transport maternal process involved in female pregnancy positive regulation of cardiac muscle contraction membrane fusion negative regulation of ERK1 and ERK2 cascade regulation of blood vessel diameter entry receptor-mediated virion attachment to host cell positive regulation of gap junction assembly regulation of cardiac conduction positive regulation of L-proline import across plasma membrane positive regulation of reactive oxygen species metabolic process regulation of cell growth positive regulation of cytokine production kidney development blood vessel remodeling regulation of blood volume by renin-angiotensin renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin regulation of blood vessel size by renin-angiotensin renal system process G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway cell-cell signaling regulation of blood pressure positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of macrophage derived foam cell differentiation response to muscle activity involved in regulation of muscle adaptation positive regulation of superoxide anion generation low-density lipoprotein particle remodeling regulation of renal sodium excretion nitric oxide-cGMP-mediated signaling pathway angiotensin-activated signaling pathway vasoconstriction regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of MAP kinase activity positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of fibroblast proliferation positive regulation of inflammatory response negative regulation of neurotrophin TRK receptor signaling pathway positive regulation of protein kinase B signaling renal sodium ion absorption positive regulation of branching involved in ureteric bud morphogenesis positive regulation of cholesterol metabolic process positive regulation of angiotensin-activated signaling pathway regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly negative regulation of sodium ion transmembrane transport positive regulation of membrane hyperpolarization positive regulation of pri-miRNA transcription from RNA polymerase II promoter response to angiotensin positive regulation of extrinsic apoptotic signaling pathway response to virus receptor biosynthetic process ovarian follicle rupture blood vessel development branching involved in ureteric bud morphogenesis regulation of systemic arterial blood pressure by circulatory renin-angiotensin angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure brain renin-angiotensin system positive regulation of extracellular matrix constituent secretion cellular sodium ion homeostasis cell-matrix adhesion cell surface receptor signaling pathway activation of phospholipase C activity activation of NF-kappaB-inducing kinase activity female pregnancy aging excretion establishment of blood-nerve barrier positive regulation of cell proliferation negative regulation of cell proliferation response to cold response to salt stress regulation of gene expression positive regulation of activation of JAK2 kinase activity positive regulation of gene expression positive regulation of cholesterol esterification negative regulation of endopeptidase activity regulation of norepinephrine secretion positive regulation of phosphatidylinositol 3-kinase signaling artery smooth muscle contraction negative regulation of angiogenesis extracellular matrix organization negative regulation of cell growth peristalsis positive regulation of cellular protein metabolic process positive regulation of peptidyl-serine phosphorylation negative regulation of tissue remodeling catenin import into nucleus positive regulation of renal sodium excretion positive regulation of multicellular organism growth vasodilation hormone metabolic process drinking behavior positive regulation of catalytic activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of fatty acid biosynthetic process positive regulation of blood pressure positive regulation of vasodilation positive regulation of organ growth astrocyte activation fibroblast proliferation regulation of long-term neuronal synaptic plasticity smooth muscle cell proliferation cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation smooth muscle cell differentiation stress-activated MAPK cascade regulation of calcium ion transport regulation of transmission of nerve impulse cell growth involved in cardiac muscle cell development positive regulation of protein tyrosine kinase activity ERK1 and ERK2 cascade uterine smooth muscle contraction cellular response to mechanical stimulus positive regulation of protein kinase C activity
          It has to be done as per old AB suggested Products section.

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