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          • Primary Antibodies ›
          • Pan Succinyl Lysine Antibodies

          Invitrogen

          Pan Succinyl Lysine Recombinant Rabbit Monoclonal Antibody (4A3S5)

          View all (2) Pan Succinyl Lysine antibodies

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          Cite Pan Succinyl Lysine Recombinant Rabbit Monoclonal Antibody (4A3S5)

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          • Antibody Testing Data (3)
          Pan Succinyl Lysine Antibody in Western Blot (WB)
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          Pan Succinyl Lysine Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 3

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          Pan Succinyl Lysine Antibody (MA568792) in WB

          Western blot analysis of Pan Succinyl Lysine in HeLa cells. Samples were probed with Pan Succinyl Lysine recombinant monoclonal antibody (Product # MA568792) at 1:1,000 dilution incubated overnight at 4°C. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 30 µg per lane. Blocking buffer: 3 % nonfat dry milk in TBST. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          Pan Succinyl Lysine Antibody in Western Blot (WB)
          Pan Succinyl Lysine Antibody in Western Blot (WB)
          Pan Succinyl Lysine Antibody in Dot Blot (DB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Product Details

          MA568792

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:5,000
          -

          ELISA (ELISA)

          1 µg/mL
          -

          Immunoprecipitation (IP)

          0.5-4 µg
          -

          Dot blot (DB)

          1:500 -1:2,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Expression System

          HEK293 cells

          Class

          Recombinant Monoclonal

          Type

          Antibody

          Clone

          4A3S5

          Immunogen

          Synthetic peptide.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1.1 mg/mL

          Amount

          110 µg

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.3., with 50% glycerol, 0.05% BSA

          Contains

          0.09% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Pan-succinyl-lysine is a post-translational modification where a succinyl group is added to the lysine residue of a protein, influencing protein function and localization. This modification generally occurs in the mitochondria, where it plays a pivotal role in the regulation of metabolic enzymes. The succinyl group is transferred to lysine residues by specific enzymes, leading to changes in protein structure and activity. Succinylation is essential for processes like the tricarboxylic acid (TCA) cycle, fatty acid metabolism, and amino acid degradation. Dysregulation of lysine succinylation is associated with various diseases, including cancer and metabolic disorders.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); carboxypeptidase A1 (pancreatic); casein kinase I; casein kinase I alpha S-like; CASP-1; caspase 1, apoptosis-related cysteine peptidase; CKI-alpha; CKI-alpha-like; class IVb beta tubulin; clock regulator kinase; CSNK1A1; cysteine protease; DNA ADP-ribosyltransferase PARP1; down-regulated in lung cancer; epididymis secretory sperm binding protein; epididymis secretory sperm binding protein Li 77p; G protein beta1/gamma2 subunit-interacting factor 1; H3 histone family, member A; HIST1H3A; histone 1, H3a; histone cluster 1 H3 family member a; histone cluster 1, H3a; histone H3/a; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; microtubule protein; microtubule-associated protein tau; NAD(+) ADP-ribosyltransferase 1; neurofibrillary tangle protein; p45; paired helical filament-tau; pancreatic carboxypeptidase A; PHF-tau; poly (ADP-ribose) polymerase family, member 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; poly[ADP-ribose] synthase 1; protein phosphatase 1, regulatory subunit 103; protein poly-ADP-ribosyltransferase PARP1; Tau-derived paired helical filament hexapeptide; tubulin beta-2 chain; tubulin beta-2C chain; tubulin, beta 2C; tubulin, beta, 2; unnamed protein product

          View more View less

          Gene Aliases: ADPRT; ADPRT 1; ADPRT1; ARTD1; Beta2; CK1; CK1a; CKIa; CPA; DDPAC; FTD1; FTDP-17; H3/A; H3FA; HEL-S-77p; HIST1H3A; HLCDGP1; ICE; IL1BC; LCAEOD; MAPTL; MSTD; MTBT1; MTBT2; P45; pADPRT-1; PARP; PARP-1; PARS; Poly-PARP; PPND; PPOL; PPP1R103; PRO2975; TAU; tau-40; Tau-PHF6; TUBB2; TUBB2C

          View more View less

          UniProt ID: (Human) P29466, (Human) P15085, (Human) P48729, (Human) Q8N752, (Mouse) P29452, (Rat) P97633, (Human) P68431, (Human) P10636, (Human) P09874, (Human) P68371

          View more View less

          Entrez Gene ID: (Human) 834, (Human) 1357, (Human) 1452, (Human) 122011, (Mouse) 12362, (Rat) 113927, (Human) 8350, (Human) 4137, (Human) 142, (Human) 10383

          View more View less

          Function(s)
          endopeptidase activity cysteine-type endopeptidase activity protein binding cysteine-type peptidase activity cysteine-type endopeptidase activator activity involved in apoptotic process enzyme binding kinase binding cytokine binding identical protein binding CARD domain binding metallocarboxypeptidase activity exopeptidase activity zinc ion binding protein kinase activity protein serine/threonine kinase activity ATP binding protein serine kinase activity peptidase activity scaffold protein binding magnesium ion binding peptide binding phosphoprotein binding DNA binding structural constituent of chromatin nucleosomal DNA binding cadherin binding protein heterodimerization activity AT DNA binding double-stranded DNA binding single-stranded DNA binding RNA binding actin binding enzyme inhibitor activity microtubule binding tubulin binding SH3 domain binding protein kinase binding protein binding, bridging apolipoprotein binding dynactin binding phosphatidylinositol binding sequence-specific DNA binding chaperone binding protein phosphatase 2A binding Hsp90 protein binding lipoprotein particle binding histone-dependent DNA binding microtubule lateral binding microtubule stabilizing activity phosphatidylinositol bisphosphate binding chromatin binding damaged DNA binding NAD+ ADP-ribosyltransferase activity enzyme activator activity estrogen receptor binding nucleosome binding ubiquitin protein ligase binding protein homodimerization activity histone deacetylase binding non-sequence-specific DNA binding, bending NAD binding RNA polymerase II sequence-specific DNA binding transcription factor binding R-SMAD binding NAD DNA ADP-ribosyltransferase activity transcription regulator activator activity NAD+-protein-serine ADP-ribosyltransferase activity NAD+-protein-aspartate ADP-ribosyltransferase activity NAD+-protein-glutamate ADP-ribosyltransferase activity NAD+-protein-tyrosine ADP-ribosyltransferase activity NAD+-protein-histidine ADP-ribosyltransferase activity NAD+-histone H2BS6 serine ADP-ribosyltransferase activity NAD+-histone H3S10 serine ADP-ribosyltransferase activity NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity single-strand break-containing DNA binding protein ADP-ribosylase activity double-stranded RNA binding GTPase activity structural constituent of cytoskeleton GTP binding MHC class I protein binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter response to hypoxia microglial cell activation plasma membrane repair positive regulation of cytokine production pattern recognition receptor signaling pathway proteolysis inflammatory response osmosensory signaling pathway myoblast fusion memory protein secretion response to xenobiotic stimulus response to bacterium regulation of autophagy programmed cell death protein processing protein autoprocessing protein catabolic process response to lipopolysaccharide positive regulation of interleukin-1 alpha production positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production response to ATP interleukin-18-mediated signaling pathway defense response to bacterium regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of circadian sleep/wake cycle, non-REM sleep ceramide biosynthetic process regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium protein maturation defense response to virus mitochondrial depolarization membrane hyperpolarization protein poly-ADP-ribosylation pyroptosis interleukin-1-mediated signaling pathway cellular response to lipopolysaccharide cellular response to interferon-gamma programmed necrotic cell death cytokine precursor processing signaling receptor ligand precursor processing AIM2 inflammasome complex assembly pyroptotic cell death positive regulation of NLRP3 inflammasome complex assembly response to paraquat positive regulation of tumor necrosis factor-mediated signaling pathway microtubule cytoskeleton organization mitotic cell cycle cytoskeleton organization microtubule-based process sperm motility natural killer cell mediated cytotoxicity apoptotic process signal transduction positive regulation of neuron apoptotic process icosanoid biosynthetic process cellular response to mechanical stimulus positive regulation of release of cytochrome c from mitochondria cell morphogenesis protein phosphorylation Golgi organization cellular response to nutrient positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of Rho protein signal transduction intermediate filament cytoskeleton organization negative regulation of canonical Wnt signaling pathway negative regulation of NLRP3 inflammasome complex assembly positive regulation of TORC1 signaling cellular response to DNA damage stimulus cell-cell signaling synapse assembly learning or memory response to lead ion negative regulation of gene expression negative regulation of mitochondrial membrane potential rRNA metabolic process axonal transport of mitochondrion central nervous system neuron development regulation of microtubule polymerization or depolymerization regulation of microtubule polymerization positive regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development positive regulation of superoxide anion generation regulation of chromosome organization stress granule assembly cellular response to heat cellular response to reactive oxygen species positive regulation of axon extension microtubule polymerization astrocyte activation regulation of synaptic plasticity intracellular distribution of mitochondria generation of neurons synapse organization regulation of calcium-mediated signaling protein polymerization protein homooligomerization regulation of microtubule-based movement axon development regulation of microtubule cytoskeleton organization plus-end-directed organelle transport along microtubule regulation of mitochondrial fission negative regulation of mitochondrial fission fibril organization axonal transport regulation of cellular response to heat regulation of long term synaptic depression positive regulation of protein localization to synapse neurofibrillary tangle assembly negative regulation of establishment of protein localization to mitochondrion positive regulation of cellular protein localization amyloid fibril formation cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus single strand break repair telomere maintenance DNA repair double-strand break repair transcription from RNA polymerase II promoter mitochondrion organization transforming growth factor beta receptor signaling pathway response to gamma radiation positive regulation of cardiac muscle hypertrophy carbohydrate biosynthetic process signal transduction involved in regulation of gene expression macrophage differentiation DNA ADP-ribosylation mitochondrial DNA metabolic process positive regulation of DNA-templated transcription, elongation cellular response to insulin stimulus regulation of protein localization positive regulation of intracellular estrogen receptor signaling pathway negative regulation of transcription elongation from RNA polymerase II promoter cellular response to oxidative stress cellular response to UV protein modification process mitochondrial DNA repair regulation of circadian sleep/wake cycle, non-REM sleep response to ethanol negative regulation of innate immune response negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter decidualization positive regulation of mitochondrial depolarization positive regulation of SMAD protein import into nucleus positive regulation of necroptotic process protein auto-ADP-ribosylation protein localization to chromatin establishment of protein localization to chromatin cellular response to zinc ion cellular response to transforming growth factor beta stimulus replication fork reversal negative regulation of cGAS/STING signaling pathway positive regulation of protein localization to nucleus cellular response to oxygen-containing compound regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway response to aldosterone negative regulation of adipose tissue development negative regulation of telomere maintenance via telomere lengthening cellular response to beta-amyloid positive regulation of myofibroblast differentiation regulation of base-excision repair positive regulation of double-strand break repair via homologous recombination ATP generation from poly-ADP-D-ribose negative regulation of ATP biosynthetic process cell surface receptor signaling pathway Wnt signaling pathway viral protein processing regulation of Wnt signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process leukotriene metabolic process response to cadmium ion chromatin organization nucleosome assembly heterochromatin assembly telomere organization regulation of gene expression, epigenetic
          It has to be done as per old AB suggested Products section.

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