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Invitrogen
Glucagon Recombinant Rabbit Monoclonal Antibody (1D6I0)
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FIGURE: 1 / 5
Glucagon Antibody (MA575469) in IHC (P)
Immunohistochemistry analysis of Glucagon in paraffin-embedded Mouse pancreas tissue. Samples were treated with antigen retrieval using 0.01M Citrate Buffer (pH 6.0), then incubated with monoclonal Glucagon (Product # MA575469) antibody at a dilution of 1:1,500, followed by Cy3 Goat Anti-Rabbit IgG (H+L) (1:500, red) and DAPI. Objective: 40x.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA575469
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1D6I0
Immunogen
Synthetic peptide. This information is considered to be commercially sensitive.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.36 mg/mL
Amount
36 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus. The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogensis, which are antagonistic effects to those of insulin action, thus leading to increased blood glucose levels. Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15-20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets. Pathological manifestations of the glucagon-type peptide residue almost exclusively with the exsistence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified. Glucagon-specific antibodies would prove useful as a cell and tumor markers applying immunohistochemical techniques, and as an analytical tool in qualification of the hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glicentin-related polypeptide; GLP1/2; glucagon-like peptide 1; glucagon-like peptide 2; glucagon-like peptide I; glucagon-like peptide-1; glucagon; glucagon-like peptide I; glucagon like-peptide II; IL12p35; IL12P40; incretin; OXY; preproglucagon; unnamed protein product
Gene Aliases: GLP-1; GLP1; GLP2; Glu; GRPP; PPG
UniProt ID: (Human) P01275, (Mouse) P55095
Entrez Gene ID: (Human) 2641, (Mouse) 14526, (Rat) 24952
cellular glucose homeostasis
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
response to activity
negative regulation of appetite
positive regulation of insulin secretion involved in cellular response to glucose stimulus
glucose homeostasis
negative regulation of apoptotic process
positive regulation of gluconeogenesis
regulation of insulin secretion
positive regulation of ERK1 and ERK2 cascade
cellular response to glucagon stimulus
positive regulation of calcium ion import
negative regulation of execution phase of apoptosis
signal transduction
G-protein coupled receptor signaling pathway
feeding behavior
positive regulation of insulin secretion
regulation of carbohydrate metabolic process
regulation of lipid metabolic process
positive regulation of adenylate cyclase activity
positive regulation of bicellular tight junction assembly
response to L-arginine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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