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Fabgennix
KAT13C/NCOA2 Polyclonal Antibody
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Product Details
NUCR2-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid 1375-1425 on rat NuCR2/GRIP-1/SRC-2 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator2, NCOA2 or TIF2, aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors, are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHe75; c-fgr; c-src2; Class E basic helix-loop-helix protein 75; FLJ43153; Glucocorticoid receptor-interacting protein 1; glucocorticoid receptor-interacting protein-1; GRIP-1; hTIF2; MGC75096; NCoA-2; Nuclear receptor coactivator 2; p160 steroid receptor coactivator 2; p55c-fgr; p58c-fgr; SRC-2; Steroid receptor coactivator 2; TIF 2; Transcriptional intermediary factor 2; unnamed protein product
Gene Aliases: BHLHE75; D1Ertd433e; GRIP-1; GRIP1; KAT13C; NCoA-2; NCOA2; SRC-2; SRC2; TIF2
UniProt ID: (Human) Q15596, (Mouse) Q61026, (Rat) Q9WUI9
Entrez Gene ID: (Human) 10499, (Mouse) 17978, (Rat) 83724
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
receptor binding
protein binding
ligand-dependent nuclear receptor binding
aryl hydrocarbon receptor binding
protein domain specific binding
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
transcription regulator inhibitor activity
histone acetyltransferase activity
signal transducer activity
transcription factor binding
PDZ domain binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
thyroid hormone receptor coactivator activity
protein complex binding
progesterone receptor binding
nuclear hormone receptor binding
glucocorticoid receptor binding
retinoic acid receptor binding
retinoid X receptor binding
thyroid hormone receptor binding
DNA polymerase binding
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
circadian rhythm
regulation of gene expression
regulation of glucose metabolic process
regulation of lipid metabolic process
response to progesterone
cellular response to hormone stimulus
circadian regulation of gene expression
peroxisome proliferator activated receptor signaling pathway
mRNA transcription from RNA polymerase II promoter
locomotor rhythm
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
regulation of cellular response to insulin stimulus
cellular response to Thyroglobulin triiodothyronine
positive regulation of adipose tissue development
transcription, DNA-templated
signal transduction
male gonad development
histone acetylation
cerebellum development
positive regulation of female receptivity
positive regulation of receptor activity
positive regulation of glucocorticoid receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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