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Invitrogen
Tyrosine Hydroxylase Polyclonal Antibody
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FIGURE: 1 / 4
Tyrosine Hydroxylase Antibody (P21962) in IHC (F)
Immunofluorescence analysis of DA neurons using anti-tyrosine hydroxylase (TH) antibody. H9 ESCs were differentiated with PSC Dopaminergic neuron differentiation kit. H9 ESCs were specified to become midbrain floor plate (FP) progenitors which were further expanded and cryopreserved. Recovered FP progenitors were then matured for additional 14 days. Expression of TH was labeled with 1st antibody, anti-TH (P... View More
Product Details
P21962
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Fruit fly,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma.
Conjugate
Form
Liquid
Purification
purified
Storage buffer
0.01M HEPES, pH 7.5, with 50% glycerol, 0.15M NaCl, 100µg/mL BSA
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: aromatic amino acid hydroxylase; dystonia 14; EC 1.14.16.2; HGNC:11782; TH; TH isoform 3; TH isoform a; TH-4; TY3H; TYH antibody; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase (EC 1.14.16.2); tyrosine hydroxylase type 4 (EC 1.14.16.2); unnamed protein product
Gene Aliases: DYT14; DYT5b; TH; The; TYH
UniProt ID: (Human) P07101, (Rat) P04177
Entrez Gene ID: (Human) 7054, (Rat) 25085
monooxygenase activity
tyrosine 3-monooxygenase activity
iron ion binding
protein binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
enzyme binding
identical protein binding
metal ion binding
ferrous iron binding
ferric iron binding
amino acid binding
oxygen binding
protein domain specific binding
tetrahydrobiopterin binding
dopamine binding
response to hypoxia
synaptic transmission, dopaminergic
heart morphogenesis
dopamine biosynthetic process from tyrosine
heart development
visual perception
learning
memory
mating behavior
locomotory behavior
regulation of heart contraction
aromatic amino acid family metabolic process
anatomical structure morphogenesis
organ morphogenesis
dopamine biosynthetic process
epinephrine biosynthetic process
norepinephrine biosynthetic process
catecholamine biosynthetic process
serotonin biosynthetic process
eye photoreceptor cell development
eating behavior
pigmentation
response to ethanol
embryonic camera-type eye morphogenesis
cognition
hyaloid vascular plexus regression
response to amphetamine
fatty acid metabolic process
sphingolipid metabolic process
sensory perception of sound
response to water deprivation
response to light stimulus
response to herbicide
response to salt stress
response to metal ion
response to zinc ion
multicellular organism aging
response to organic cyclic compound
response to activity
aminergic neurotransmitter loading into synaptic vesicle
glycoside metabolic process
response to insecticide
phthalate metabolic process
cerebral cortex development
response to nutrient levels
response to estradiol
response to lipopolysaccharide
isoquinoline alkaloid metabolic process
response to nicotine
social behavior
cellular response to drug
response to isolation stress
response to immobilization stress
neurotransmitter biosynthetic process
terpene metabolic process
response to drug
circadian sleep/wake cycle
response to peptide hormone
response to ether
response to pyrethroid
response to steroid hormone
protein homotetramerization
response to corticosterone
response to electrical stimulus
phytoalexin metabolic process
oxidation-reduction process
response to growth factor
cellular response to manganese ion
cellular response to alkaloid
cellular response to nicotine
cellular response to glucose stimulus
cellular response to growth factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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