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Invitrogen

BDNF Polyclonal Antibody

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BDNF Polyclonal Antibody

Product Details

PA1-18372

Applications
Tested Dilution
Publications

Western Blot (WB)

1-10 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

1-10 µg/mL
-

Immunocytochemistry (ICC/IF)

1:200
-

ELISA (ELISA)

1-10 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues H(129) S D P A R R G E L(138) of human BDNF.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL once reconstituted

Amount

500 µg

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2064216

Product Specific Information

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Target Information

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: abrineurin; BDNF; brain derived neurothrophic factor; brain-derived neurotrophic factor; growth factor; BDNF; H-BDNF; hBDNF1; hBDNF2A; hBDNF2B; hBDNF2C; hBDNF3; hBDNF4; hBDNF5; hBDNF6A; hBDNF6B; hBDNF7; neurotrophic factor; neurotrophin; proBDNF; unnamed protein product

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Gene Aliases: ANON2; BULN2

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UniProt ID: (Human) P23560, (Rat) P23363

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Entrez Gene ID: (Human) 627, (Rat) 24225

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Function(s)
receptor binding nerve growth factor receptor binding protein binding growth factor activity neurotrophin TRKB receptor binding
Process(es)
transmembrane receptor protein tyrosine kinase signaling pathway nervous system development axon guidance synapse assembly circadian rhythm negative regulation of myotube differentiation positive regulation of neuron projection development nerve development brain-derived neurotrophic factor receptor signaling pathway positive regulation of brain-derived neurotrophic factor receptor signaling pathway nerve growth factor signaling pathway negative regulation of neuron apoptotic process collateral sprouting positive regulation of collateral sprouting neuron projection morphogenesis modulation of synaptic transmission positive regulation of synapse assembly trans-synaptic signaling by BDNF, modulating synaptic transmission regulation of protein localization to cell surface negative regulation of apoptotic signaling pathway ureteric bud development behavioral fear response response to hypoxia chronic inflammatory response mitochondrial electron transport, NADH to ubiquinone gamma-aminobutyric acid signaling pathway negative regulation of neuroblast proliferation axon target recognition learning or memory learning feeding behavior neuron recognition response to xenobiotic stimulus response to light stimulus response to light intensity response to hormone response to auditory stimulus glutamate secretion response to activity dendrite development neuron differentiation regulation of axon extension regeneration neuron projection regeneration response to nutrient levels response to food negative regulation of synaptic transmission, GABAergic positive regulation of peptidyl-serine phosphorylation response to vitamin A response to tumor necrosis factor response to potassium ion cellular response to potassium ion mechanoreceptor differentiation fear response negative regulation of apoptotic process negative regulation of programmed cell death response to morphine regulation of neuron apoptotic process positive regulation of neuron apoptotic process response to ethanol positive regulation of neuron differentiation negative regulation of striated muscle tissue development positive regulation of transcription from RNA polymerase II promoter regulation of retinal cell programmed cell death behavioral response to cocaine regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity regulation of short-term neuronal synaptic plasticity regulation of collateral sprouting axon extension positive regulation of axon regeneration inner ear development cognition response to electrical stimulus response to hyperoxia excitatory postsynaptic potential inhibitory postsynaptic potential taste bud development cellular response to tumor necrosis factor cellular response to norepinephrine stimulus response to anesthetic dendrite extension response to L-glutamate response to nerve growth factor cellular response to nerve growth factor stimulus neuron projection extension conditioned place preference positive regulation of glucocorticoid receptor signaling pathway
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