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Invitrogen

TrkB Polyclonal Antibody

View all (78) TrkB antibodies

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TrkB Polyclonal Antibody

Product Details

PA1-18403

Applications
Tested Dilution
Publications

Immunohistochemistry (Frozen) (IHC (F))

1:1,000-1:3,000
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Extracellular domain of glycosylated mouse TrkB protein produced in CHO cells.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2155258

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Target Information

NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AI848316; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB/GP95-TrkB; GP145TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; Ntrk2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; Trk B; trkB tyrosine kinase; trkB.T1; tyrosine protein kinase B (trkB) precursor; unnamed protein product

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Gene Aliases: GP145-TrkB/GP95-TrkB; RATTRKB1; Tkrb; trk-B; trkB; TRKB1

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UniProt ID: (Mouse) P15209, (Rat) Q63604

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Entrez Gene ID: (Mouse) 18212, (Rat) 25054

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Function(s)
protease binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity neurotrophin receptor activity protein binding ATP binding receptor tyrosine kinase binding protein homodimerization activity neurotrophin binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity transmembrane receptor protein serine/threonine kinase activity
Process(es)
vasculogenesis neuron migration transmembrane receptor protein tyrosine kinase signaling pathway neuromuscular junction development learning or memory learning long-term memory circadian rhythm feeding behavior positive regulation of cell proliferation positive regulation of gene expression regulation of neuron projection development positive regulation of neuron projection development glutamate secretion neuronal action potential propagation central nervous system neuron development cerebral cortex development myelination in peripheral nervous system neuron differentiation positive regulation of cell projection organization brain-derived neurotrophic factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation neurotrophin signaling pathway mechanoreceptor differentiation negative regulation of apoptotic process regulation of GTPase activity regulation of MAPK cascade positive regulation of MAPK cascade negative regulation of neuron apoptotic process retinal rod cell development protein autophosphorylation regulation of neurotransmitter secretion regulation of synaptic plasticity oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development positive regulation of synaptic transmission regulation of cytosolic calcium ion concentration regulation of protein kinase B signaling positive regulation of protein kinase B signaling positive regulation of nervous system development positive regulation of synaptic transmission, glutamatergic retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus trans-synaptic signaling by BDNF, modulating synaptic transmission positive regulation of long term synaptic depression negative regulation of beta-amyloid formation cellular response to brain-derived neurotrophic factor stimulus positive regulation of glucocorticoid receptor signaling pathway positive regulation of excitatory postsynaptic potential negative regulation of anoikis transmembrane receptor protein serine/threonine kinase signaling pathway response to light stimulus response to auditory stimulus response to ethanol cellular response to tumor necrosis factor cellular response to nerve growth factor stimulus
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