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Invitrogen
PCSK1 Polyclonal Antibody
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Product Details
PA1-20317
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant, full length, rabbit PC1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-20317 detects PC1 in human, rat and non-human primate samples.
Target Information
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.4.21.93; NEC 1; ORF with similarities to Kex2 and furin proteins; putative; prohormone convertase 1; prohormone convertase 3; proprotein convertase 1; proprotein convertase 1/3; Protein convertase subtilisin / kexin, type I; unnamed protein product
Gene Aliases: BDP; BMIQ12; NEC1; PC1; PC1/3; PC3; SPC3
UniProt ID: (Human) P29120, (Rat) P28840
Entrez Gene ID: (Human) 5122, (Rat) 25204
proteolysis
cell-cell signaling
protein processing
peptide hormone processing
insulin processing
peptide biosynthetic process
response to xenobiotic stimulus
response to glucose
response to chlorate
protein autoprocessing
pituitary gland development
neurogenesis
pancreas development
response to nutrient levels
response to lipopolysaccharide
response to peptide hormone
response to axon injury
positive regulation of protein secretion
response to glucocorticoid
response to calcium ion
response to fatty acid
response to interleukin-1
response to forskolin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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