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Invitrogen
GM-CSF Polyclonal Antibody
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Product Details
PA1-28021
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Purified recombinant rat GM-CSF expressed in E. coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.20 mg/mL
Amount
25 µg
Purification
Affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; granulocyte macrophage colony stimulating factor; M-GM-CSF; MGC131935; MGC138897; MGC151255; MGC151257
Gene Aliases: Gm-csf; Gmcsf
UniProt ID: (Rat) P48750
Entrez Gene ID: (Rat) 116630
histamine secretion
embryonic placenta development
immune response
JAK-STAT cascade
positive regulation of cell proliferation
regulation of gene expression
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
myeloid cell differentiation
neutrophil differentiation
monocyte differentiation
macrophage differentiation
positive regulation of cell migration
TOR signaling
positive regulation of interleukin-23 production
response to silicon dioxide
response to fluid shear stress
granulocyte-macrophage colony-stimulating factor signaling pathway
epithelial fluid transport
regulation of cell proliferation
myeloid dendritic cell differentiation
regulation of circadian sleep/wake cycle, sleep
positive regulation of macrophage differentiation
negative regulation of transcription, DNA-templated
epithelial cell proliferation
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
positive regulation of leukocyte proliferation
cellular response to lipopolysaccharide
positive regulation of podosome assembly
cellular response to granulocyte macrophage colony-stimulating factor stimulus
dendritic cell differentiation
receptor signaling pathway via STAT
positive regulation of trophectodermal cell proliferation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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