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Invitrogen
Dystrophin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-37587
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from C-terminus of human dystrophin.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.26 mg/mL
Amount
260 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.6, with 1% BSA
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, chicken, canine and porcine based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is skeletal muscle tissue.
Target Information
Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immunohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DMD; Dpm234; Duchenne muscular dystrophy (DMD); dystrophin; dystrophin delta-E40e; dystrophin Dp427-E40e; dystrophin Dp71d(delta71,73-74); dystrophin Dp71f-delta71,74; dystrophin E40e; dystrophin E51b; GS1-19O24.1; Muscular dystrophy Duchenne and Becker types; mutant dystrophin; OTTHUMP00000215592; unnamed protein product; X-linked muscular dystrophy
Gene Aliases: BMD; CMD3B; Dp427; Dp71; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; DXSmh7; DXSmh9; dys; mdx; MRX85; pke
UniProt ID: (Human) P11532, (Mouse) P11531
Entrez Gene ID: (Human) 1756, (Mouse) 13405
positive regulation of cell-matrix adhesion
regulation of heart rate
regulation of transcription, DNA-templated
apoptotic process
striated muscle contraction
inflammatory response
muscle organ development
skeletal muscle tissue development
establishment of blood-nerve barrier
protein localization
positive regulation of cell proliferation
determination of adult lifespan
response to xenobiotic stimulus
gene expression
regulation of gene expression
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
positive regulation of neuron projection development
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
regulation of skeletal muscle contraction
response to denervation involved in regulation of muscle adaptation
myotube cell development
olfactory nerve structural organization
cerebral cortex development
cell differentiation
neuron differentiation
multicellular organism growth
response to muscle stretch
regulation of membrane potential
muscle cell differentiation
peptide biosynthetic process
skeletal muscle tissue regeneration
negative regulation of neuron differentiation
positive regulation of neuron differentiation
muscle cell cellular homeostasis
neuron development
neuron projection morphogenesis
nucleus localization
muscle cell development
striated muscle cell development
cardiac muscle contraction
limb development
bone development
establishment of glial blood-brain barrier
connective tissue development
protein-containing complex assembly
negative regulation of ERK1 and ERK2 cascade
cardiac muscle cell action potential
regulation of muscle system process
regulation of cellular response to growth factor stimulus
walking behavior
synaptic signaling
regulation of sodium ion transmembrane transport
regulation of calcium ion transmembrane transport
reactive oxygen species biosynthetic process
muscle contraction
cytoskeleton organization
maintenance of blood-brain barrier
camera-type eye development
regulation of system process
motile cilium assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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