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Invitrogen
TRAF3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-41107
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to amino acids between 300 and 350 of human TRAF3.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: 3T3 whole cell lysate, HeLa or NIH-3T3, antigen standard for TRAF3 (transient overexpression lysate).
Target Information
Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e. g. RANK, CD30, CD40, etc. ) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha (TNF-alpha) receptor-associated factors. TRAF3 binds only a single site, which contains the sequence PEQET, whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD40 associated protein 1; CD40 binding protein; CD40 receptor associated factor 1; CD40 receptor-associated factor 1; CD40-binding protein; LMP1-associated protein 1; RING-type E3 ubiquitin transferase TRAF3; unnamed protein product
Gene Aliases: amn; CAP-1; CD40bp; CRAF1; IIAE5; IMD132A; IMD132B; LAP1; RNF118; T-BAM; TRAFAMN
UniProt ID: (Human) Q13114, (Mouse) Q60803
Entrez Gene ID: (Human) 7187, (Mouse) 22031
ubiquitin-protein transferase activity
tumor necrosis factor receptor binding
protein binding
zinc ion binding
protein kinase binding
protein phosphatase binding
ubiquitin protein ligase binding
thioesterase binding
signaling adaptor activity
identical protein binding
ubiquitin protein ligase activity
enzyme binding
regulation of cytokine production
toll-like receptor signaling pathway
apoptotic process
signal transduction
cell surface receptor signaling pathway
Toll signaling pathway
regulation of proteolysis
regulation of type I interferon production
positive regulation of type I interferon production
regulation of interferon-beta production
tumor necrosis factor-mediated signaling pathway
toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of defense response to virus
defense response to virus
type I interferon signaling pathway
antiviral innate immune response
mRNA transcription
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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