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Invitrogen
CGRP Polyclonal Antibody
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FIGURE: 1 / 1
CGRP Antibody (PA1-85250) in IHC
BMC biology 2020 -
Fig. 5 Peripheral TRPA1 and central TRPV4 contribute to thalidomide-induced mechanical allodynia. a , b Mechanical allodynia at day 7 following intraperitoneal (i.p.) thalidomide (Thal, 50 mg/kg) or Veh and after the administration of intraplantar (i.pl., 20 mul) or intrathecal (i.th., 5 mul) HC-030031 (HC03, 100 mug), HC-067047 (HC06, 100 mug), or Veh. c , d Mechanical allodynia at day 7 following Thal (50... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-85250
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic rat Tyr-CGRP (23-37).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
5 mg/mL
Amount
500 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Goat anti Rat Calcitonin Gene-Related Peptide antibody recognizes Calcitonin gene-related peptide, also known as CGRP, a neuropeptide that acts as a vasodilator and plays a role in in the pathophysiology of migraine (Recober & Russo 2009).
Target Information
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-CGRP; alpha-type calcitonin gene-related peptide; alpha-type CGRP; calcitonin gene-related peptide I; calcitonin precursor; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; MGC126648; neuropeptide; alpha-CGRP; procalcitonin; RAT calcitonin; unnamed protein product
Gene Aliases: CA; Cal1; CAL6; Calc; Calc1; calcitonin; CGRP; CGRP-1; CGRP1; Ct; Ctn; RATCAL6
UniProt ID: (Mouse) P70160, (Rat) P01256
Entrez Gene ID: (Mouse) 12310, (Rat) 24241
endothelial cell proliferation
vasculature development
neurological system process involved in regulation of systemic arterial blood pressure
vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
regulation of heart rate
G-protein coupled receptor internalization
monocyte chemotaxis
protein phosphorylation
cellular calcium ion homeostasis
inflammatory response
leukocyte cell-cell adhesion
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
embryo implantation
feeding behavior
response to heat
negative regulation of calcium ion transport into cytosol
negative regulation of ossification
receptor internalization
negative regulation of neurological system process
activation of protein kinase activity
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-8 production
vasodilation
endothelial cell migration
positive regulation of macrophage differentiation
negative regulation of osteoclast differentiation
negative regulation of blood pressure
positive regulation of ossification
negative regulation of bone resorption
negative regulation of transcription, DNA-templated
negative regulation of smooth muscle contraction
sperm capacitation
response to pain
detection of temperature stimulus involved in sensory perception of pain
regulation of cytosolic calcium ion concentration
calcitonin family receptor signaling pathway
amylin receptor 1 signaling pathway
amylin receptor 2 signaling pathway
cellular response to nerve growth factor stimulus
calcitonin gene-related peptide receptor signaling pathway
innate immune response
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular response to tumor necrosis factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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