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Invitrogen
SSTR5 Polyclonal Antibody
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FIGURE: 1 / 1
SSTR5 Antibody (PA3-112) in WB
Western blot analysis was performed on whole cell extracts (20 µg lysate) of Hep G2 (Lane 1), PC-3 (Lane 2), MCF7 (Lane 3), Mouse Heart (lane 4), HEK-293 (lane 5), HeLa (lane 6) and Mouse Kidney (lane 9). The blots were probed with Anti-Somatostatin Receptor 5 Rabbit Polyclonal Antibody (Product # PA3-112, 1:4000-1:6000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). Two bands ~ 42 and 39 kDa corresponding to ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA3-112
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues Q(344) E A T R P A H R A A A N G L M Q T S K L(364) of human SSTR5.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA3-112 detects the Somatostatin Receptor 5 in human samples.
PA3-112 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR5 transfected HEK-293 cells this antibody detects a ~54-63 kDa protein representing SSTR5.
The PA3-112 immunogen is a synthetic peptide corresponding to residues Q(344) E A T P P A H R A A A N G L M Q T S K L(364) of human SSTR5.
Target Information
Somatostatin is a multifunctional protein affecting exocrine and endocrine protein secretion, neurotransmission, and neuronal modulation and regulating cell proliferation. All these functions of Somatostatin are executed through a class of GPCR protein family members called somatostatin receptor. Till date, 6 classes of somatostatin receptors have been discovered out of which SSTR5, 364A.A protein, is a receptor subtype expressed predominantly in the pituitary and hypothalamus region of brain. Studies revealed that SSTR5 contains seven transmembrane regions and undergoes homodimerization and also heterodimerizes with SSTR1. Although the specific functions of SSTR5 are still elusive, the studies indicate that it complements SSTR2 regulation of ACTH secretion. Polymorphisms in SSTR5 gene have been observed in patients with acromegaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: membrane receptor; SSTR5B; membrane receptor; SSTR5C; somatostatin receptor; somatostatin receptor subtype 5; SS-5-R; SS5-R; SS5R; unnamed protein product
Gene Aliases: Smstr5; SS-5-R; SST5
UniProt ID: (Human) P35346, (Mouse) O08858
Entrez Gene ID: (Human) 6755, (Mouse) 20609
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
neuropeptide signaling pathway
negative regulation of cell proliferation
positive regulation of cytokinesis
somatostatin signaling pathway
regulation of insulin secretion
cellular response to glucocorticoid stimulus
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
glucose homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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