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Invitrogen
Factor XIII A Polyclonal Antibody
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Product Details
PA5-110642
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Factor XIII A. Recombinant protein control fragment (Product #RP-100517).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LNVTSVHLFK ERWDTNKVDH HTDKYENNKL IVRRGQSFYV QIDFSRPYDP RRDLFRVEYV IGRYPQENKG TYIPVPIVSE LQSGKWGAKI VMREDRSVRL SIQSSPKCIV GKFRMYVAVW TPYGVLRTSR NPETDT
Highest antigen sequence indentity to the following orthologs: Mouse - 87%, Rat - 87%.
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bA525O21.1 (coagulation factor XIII, A1 polypeptide); Coagulation factor XIII A chain; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; Coagulation factor XIIIa; factor viiia; factor XIIIa; fibrin stabilizing factor, A subunit; fibrinoligase; FSF, A subunit; Protein-glutamine gamma-glutamyltransferase A chain; RP11-232H4.1; TGase; Transglutaminase A chain; transglutaminase. plasma
Gene Aliases: F13A; F13A1
UniProt ID: (Human) P00488
Entrez Gene ID: (Human) 2162
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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