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Invitrogen
TRF2 Polyclonal Antibody
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FIGURE: 1 / 5
TRF2 Antibody (PA5-110658) in IHC (P)
Immunohistochemistry analysis of TRF2 in human cerebral cortex, gastrointestinal, lymphoid tissues and testis. Samples were incubated with TRF2 polyclonal antibody (Product # PA5-110658). Shows similar protein distribution across tissues to independent TRF2 antibody (Product # PA5-81990) (B).
Product Details
PA5-110658
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human TRF2. Recombinant protein control fragment (Product #RP-101880).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DIMQALLVRP LGKEHTVSRL LRVMQCLSRI EEGENLDCSF DMEAELTPLE SAINVLEMIK TEFTLTEAVV ESSRKLVKEA AVIICIKNKE FEKASKILKK HMSKDPTTQK LRNDLLNIIR EKNLAHPVIQ NF
Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 96%.
Target Information
TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Telomeric DNA-binding protein; telomeric protein; telomeric repeat binding protein 2; Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2
Gene Aliases: TERF2; TRBF2; TRF2
UniProt ID: (Human) Q15554
Entrez Gene ID: (Human) 7014
telomere maintenance
in utero embryonic development
RNA-dependent DNA biosynthetic process
telomere capping
telomeric loop formation
protection from non-homologous end joining at telomere
regulation of telomere maintenance
negative regulation of telomere maintenance
positive regulation of telomere maintenance
negative regulation of telomere maintenance via recombination
regulation of telomere maintenance via telomerase
negative regulation of telomere maintenance via telomerase
negative regulation of telomere maintenance via semi-conservative replication
telomeric D-loop disassembly
protein localization to chromosome, telomeric region
cellular senescence
axonal transport of messenger ribonucleoprotein complex
negative regulation of telomere single strand break repair
negative regulation of telomere capping
negative regulation of telomere maintenance via telomere lengthening
negative regulation of t-circle formation
negative regulation of telomeric D-loop disassembly
negative regulation of cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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