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Invitrogen

ROC1 Polyclonal Antibody

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ROC1 Polyclonal Antibody

Product Details

PA5-110664

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human ROC1. Recombinant protein control fragment (Product #RP-91505).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2856075

Product Specific Information

Immunogen sequence: MAAAMDVDTP SGTNSGAGKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WEF

Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.

Target Information

This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein transferase RBX1; Protein ZYP; RBX1; Regulator of cullins 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; ROC1; unnamed protein product; ZYP protein

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Gene Aliases: BA554C12.1; RBX1; RNF75; ROC1

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UniProt ID: (Human) P62877

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Entrez Gene ID: (Human) 9978

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Function(s)
ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity NEDD8 transferase activity ubiquitin protein ligase binding ubiquitin-ubiquitin ligase activity macromolecular complex binding metal ion binding binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding ubiquitin protein ligase activity NEDD8 ligase activity cullin family protein binding
Process(es)
autophagosome assembly G1/S transition of mitotic cell cycle MAPK cascade protein polyubiquitination mitophagy epithelial to mesenchymal transition DNA repair transcription-coupled nucleotide-excision repair transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter ubiquitin-dependent protein catabolic process protein monoubiquitination apoptotic process cellular response to DNA damage stimulus response to oxidative stress lysosome organization spermatogenesis regulation of mitotic cell cycle insulin receptor signaling pathway negative regulation of autophagy positive regulation of autophagy protein ubiquitination cytokine-mediated signaling pathway protein catabolic process DNA damage response, signal transduction by p53 class mediator SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cellular response to nutrient levels negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of type I interferon production positive regulation of type I interferon production cellular response to insulin stimulus cellular response to amino acid starvation cellular response to oxidative stress cellular response to UV mRNA cleavage involved in gene silencing by miRNA p38MAPK cascade TORC1 signaling T cell activation signal transduction in response to DNA damage positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process post-translational protein modification protein neddylation positive regulation of translation positive regulation of protein catabolic process positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin receptor signaling pathway type I interferon signaling pathway cellular response to chemical stress renal sodium ion absorption protein K48-linked ubiquitination cellular response to amino acid stimulus negative regulation of canonical Wnt signaling pathway base-excision repair, AP site formation via deaminated base removal ubiquitin-dependent protein catabolic process via the C-end degron rule pathway RNA polymerase II transcription initiation surveillance regulation of cellular response to insulin stimulus negative regulation of macromitophagy negative regulation of signal transduction by p53 class mediator positive regulation of protein autoubiquitination negative regulation of response to oxidative stress positive regulation of epithelial cell apoptotic process negative regulation of TORC1 signaling positive regulation of TORC1 signaling negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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