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Invitrogen
IL-18 Polyclonal Antibody
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Product Details
PA5-110679
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human IL-18. Recombinant protein control fragment (Product #RP-102266).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN LNDQVLFIDQ GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ F
Highest antigen sequence indentity to the following orthologs: Rat - 62%, Mouse - 61%.
Target Information
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytokine; Iboctadekin; IFN-gamma-inducing factor; il 18; IL-1 gamma; IL-18; IL18; ILN; Interferon gamma-inducing factor; interferon-gamma-inducing factor; Interleukin; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; Interleukin-18; Interleukin18; MGC12320
Gene Aliases: IGIF; IL-18; IL-1g; IL18; IL1F4
UniProt ID: (Human) Q14116
Entrez Gene ID: (Human) 3606
angiogenesis
inflammatory response
immune response
cell surface receptor signaling pathway
cell-cell signaling
cell proliferation
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
cytokine-mediated signaling pathway
natural killer cell activation
regulation of cell adhesion
sleep
positive regulation of chemokine production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-13 production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
positive regulation of tissue remodeling
interleukin-18-mediated signaling pathway
T-helper 1 type immune response
type 2 immune response
positive regulation of activated T cell proliferation
neutrophil activation
natural killer cell mediated cytotoxicity
positive regulation of tyrosine phosphorylation of STAT protein
cholesterol homeostasis
positive regulation of T-helper 2 cell differentiation
negative regulation of myoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of NK T cell proliferation
positive regulation of protein kinase B signaling
establishment of skin barrier
triglyceride homeostasis
cellular response to lipopolysaccharide
positive regulation of cold-induced thermogenesis
positive regulation of neuroinflammatory response
positive regulation of NIK/NF-kappaB signaling
positive regulation of T-helper 1 cell cytokine production
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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