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Invitrogen
KIF2A Polyclonal Antibody
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Product Details
PA5-110684
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human KIF2A. Recombinant protein control fragment (Product #RP-102374).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DNESVTVEWI ENGDTKGKEI DLESIFSLNP DLVPDEEIEP SPETPPPPAS SAKVNKIVKN RRTVASIKND PPSRDNRVVG SARARPSQFP EQSSSAQQNG SVSDISPVQA
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 92%.
Target Information
KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hK2; kif2a {ECO:0000250|UniProtKB:O00139}; kinesin family member 2A; kinesin heavy chain family, member 2; kinesin heavy chain member 2; kinesin heavy chain member 2A; Kinesin, heavy chain, 2; Kinesin-2; Kinesin-like protein KIF2A
Gene Aliases: CDCBM3; HK2; KIF2; KIF2A; KNS2
UniProt ID: (Human) O00139
Entrez Gene ID: (Human) 3796, (Rat) 84391
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
mitotic spindle organization
sister chromatid cohesion
nervous system development
antigen processing and presentation of exogenous peptide antigen via MHC class II
cell differentiation
cell division
mitotic spindle assembly
microtubule depolymerization
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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