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Invitrogen
AATF Polyclonal Antibody
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Product Details
PA5-110691
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human AATF. Recombinant protein control fragment (Product #RP-102494).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SVQSISDFEK FTKGMDDLGS SEEEEDEESG MEEGDDAEDS QGESEEDRAG DRNSEDDGVV MTFSSVKVSE EVEKGRAVKN QIALWDQLLE GRIKLQKALL TTNQLPQPDV FPLFKDKGGP EFSSALKNSH KALKALLTSL VGLQ
Highest antigen sequence indentity to the following orthologs: Rat - 66%, Mouse - 72%.
Target Information
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis-antagonizing transcription factor; Protein AATF; Rb-binding protein Che-1
Gene Aliases: AATF; BFR2; CHE-1; CHE1; DED; HSPC277
UniProt ID: (Human) B3KQ26
Entrez Gene ID: (Human) 26574
cellular response to DNA damage stimulus
cell adhesion
regulation of mitotic cell cycle
negative regulation of superoxide anion generation
embryonic cleavage
ribosome biogenesis
negative regulation of amyloid precursor protein biosynthetic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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