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Invitrogen
BRIP1 Polyclonal Antibody
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Product Details
PA5-110693
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human BRIP1. Recombinant protein control fragment (Product #RP-102519).
Conjugate
Form
Liquid
Concentration
0.30 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FNKQTKRVSW SSFNSLGQYF TGKIPKATPE LGSSENSASS PPRFKTEKME SKTVLPFTDK CESSNLTVNT SFGSCPQSET IISSLKIDAT LTRKNHSEHP LCSEEALDPD IELSLVSEED KQSTSNRDFE TEAEDESIYF TPEL
Highest antigen sequence indentity to the following orthologs: Mouse - 47%, Rat - 47%.
Target Information
BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) is a gene situated on chromosome 17q22, covering 19 exons within its 184-kb coding region to encode a protein containing 1249 amino acids. BRIP1 is integral to the DNA repair processes, specifically through its interaction with the BRCA1 gene, and is involved in the Fanconi anemia complementation group J (FANC J). Mutations in BRIP1 have been identified, playing a role in cancer predisposition with a notable eightfold increased risk for ovarian cancer and associations with cervical cancer risk through its single nucleotide polymorphisms (SNPs). Amplifications and other mutations of BRIP1 are prevalent in a variety of cancers, and its expression involves significant correlations with copy number variations (CNV) and DNA methylation across numerous tumor types. BRIP1's expression is upregulated in certain contexts, which can contribute to cancer progression, as evidenced in the Omani population with breast cancer. These interactions validate its association with DNA damage repair, cell cycle, and metabolism across multiple cancer types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent RNA helicase BRIP1; BACH 1; BACH1 BRIP1; BRCA1 interacting helicase 1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1/BRCA2-associated helicase 1; BRCT-binding helicase-like protein BACH1; BRIP 1; DNA 5'-3' helicase FANCJ; FANCJ helicase; FANCJ protein; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; unnamed protein product
Gene Aliases: BACH1; BRIP1; FANCJ; OF
UniProt ID: (Human) Q9BX63
Entrez Gene ID: (Human) 83990
nucleotide binding
nucleic acid binding
DNA binding
DNA helicase activity
RNA helicase activity
helicase activity
protein binding
ATP binding
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
isomerase activity
ATPase activity
5'-3' DNA helicase activity
metal ion binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
catalytic activity, acting on a nucleic acid
DNA damage checkpoint
nucleobase-containing compound metabolic process
DNA repair
nucleotide-excision repair
double-strand break repair
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
synapsis
spermatogenesis
spermatogonial cell division
spermatid development
male gonad development
meiotic DNA double-strand break processing involved in reciprocal meiotic recombination
reciprocal DNA recombination
interstrand cross-link repair
chiasma assembly
seminiferous tubule development
protein-DNA covalent cross-linking repair
double-strand break repair involved in meiotic recombination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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