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Invitrogen
TAOK1 Polyclonal Antibody
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Product Details
PA5-110734
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human TAOK1. Recombinant protein control fragment (Product #RP-89799).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LSPEAFSHSY PGASGWSHNP TGGPGPHWGH PMGGPPQAWG HPMQGGPQPW GHPSGPMQGV PRGSSMGVRN SPQALRRTAS GGRTEQGMSR STSVTSQISN GSH
Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 98%.
Target Information
TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs). The activation of and binding to MEK3 by TAOK1 implicates TAOK1 in the regulation of the p38-containing stress-responsive MAP kinase pathway. A microtubule affinity-regulating kinase, TAOK1 (also known as MARKK) is an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay. TAOK1 is involved in various processes such as p38/MAPK14 stress-activated MAPK cascase, DNA damage response, and regulations of cytoskeleton stability. It phosphorylates MAP2K3, MAP2K6, and MARK2. TAOK1 acts as an activator of the p38/MAPK cascade by mediating phosphorylation and subsequent activation of the upsteam MAP2K3 and MAP2K6 kinases. It is involved in G-protein couples receptor signaling to p38/MAPK14. In response to DNA damage, TAOK1, is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade by phosphorylaton of MAP2K3 and MAP2K6. In addition, it acts as a regulator of cytoskeleton stability and a regulator of apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ14314; h hTAOK1; H KIAA1361; hKFC-B; Kinase from chicken homolog B; MARK Kinase; MARKK; microtubule affinity regulating kinase kinase; prostate-derived STE20-like kinase 2; Prostate-derived sterile 20-like kinase 2; PSK-2; serine/threonine protein kinase TAO1 homolog; Serine/threonine-protein kinase TAO1; STE20-like kinase PSK2; tao; TAOK1; thousand and one amino acid protein 1; Thousand and one amino acid protein kinase 1; unnamed protein product
Gene Aliases: DDIB; hKFC-B; hTAOK1; KFC-B; KIAA1361; MAP3K16; MARKK; PSK-2; PSK2; TAO1; TAOK1
UniProt ID: (Human) Q7L7X3
Entrez Gene ID: (Human) 57551
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
alpha-tubulin binding
protein serine/threonine kinase activator activity
tau protein binding
beta-tubulin binding
tau-protein kinase activity
protein serine kinase activity
microtubule cytoskeleton organization
DNA repair
apoptotic process
cellular response to DNA damage stimulus
negative regulation of microtubule depolymerization
mitotic G2 DNA damage checkpoint
central nervous system neuron development
positive regulation of stress-activated MAPK cascade
regulation of actin cytoskeleton organization
positive regulation of JNK cascade
regulation of cytoskeleton organization
neuron cellular homeostasis
regulation of microtubule cytoskeleton organization
execution phase of apoptosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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