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Invitrogen
DKK3 Polyclonal Antibody
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Product Details
PA5-110767
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human DKK3. Recombinant protein control fragment (Product #RP-89882).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CGDQLCVWGH CTKMATRGSN GTICDNQRDC QPGLCCAFQR GLLFPVCTPL PVEGELCHDP ASRLLDLITW ELEPDGALDR CPCASGLLCQ PHSHSLVYVC KPTFVGSRDQ DGEILLPREV PDEYLAASW
Highest antigen sequence indentity to the following orthologs: Mouse - 83%, Rat - 81%.
Target Information
DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dickkopf; dickkopf 3; dickkopf 3 homolog; Dickkopf gene 3; dickkopf homolog 3; Dickkopf-3; Dickkopf-related protein 3; Dickkopf3; DKK 3; dkk-3; hDkk 3; hDkk-3; hhDkk3; regulated in glioma; RIG-like 5-6; RIG-like 7-1; Xenopus
Gene Aliases: DKK3; REIC; RIG; UNQ258/PRO295
UniProt ID: (Human) Q9UBP4
Entrez Gene ID: (Human) 27122
anatomical structure morphogenesis
Wnt signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
adrenal gland development
negative regulation of aldosterone biosynthetic process
negative regulation of transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway
negative regulation of anti-Mullerian hormone signaling pathway
negative regulation of cortisol biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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