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Invitrogen
TNK1 Polyclonal Antibody
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Product Details
PA5-110771
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human TNK1. Recombinant protein control fragment (Product #RP-89813).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PSEACCVRDV TEPGALRMET GDPITVIEGS PDSTIWKGQN GRTFKVGSFP ASAVTLADAG GLPATRPVHR GTPARGDQHP GSIDGDRKKA NLWDAPPARG QRRNMPLERM KGISRSLESV LSLG
Highest antigen sequence indentity to the following orthologs: Rat - 76%, Mouse - 71%.
Target Information
TNK1 tyrosine kinase, non-receptor 1 belongs to the tyrosine protein kinase family and as such is an important regulator of intracellular signal transduction pathways mediating cellular proliferation, survival, and development. TNK1 is highly expressed in fetal tissues and at lower levels in a few adult tissues. TNK1 may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. TNK1 plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD38 negative kinase 1; MGC46193; Non-receptor tyrosine-protein kinase TNK1
Gene Aliases: KOS1; TNK1
UniProt ID: (Human) Q13470
Entrez Gene ID: (Human) 8711
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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