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Invitrogen
TEM7 Polyclonal Antibody
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Product Details
PA5-110778
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human TEM7. Recombinant protein control fragment (Product #RP-90375).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RSCDACMSSD LTFNCSWCHV LQRCSSGFDR YRQEWMDYGC AQEAEGRMCE DFQDEDHDSA SPDTSFSPYD GDLTTTSSSL FIDSLTTEDD TKLNPYAGGD GLQNNLSPKT KGTPVHLG
Highest antigen sequence indentity to the following orthologs: Rat - 83%, Mouse - 81%.
Target Information
Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2410003I07Rik; DKFZp686F0937; FLJ36270; FLJ45632; Plexin domain-containing protein 1; Tumor endothelial marker 3; Tumor endothelial marker 7
Gene Aliases: PLXDC1; TEM3; TEM7
UniProt ID: (Human) Q8IUK5
Entrez Gene ID: (Human) 57125
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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