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Invitrogen
CYP11A1 Polyclonal Antibody
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CYP11A1 Antibody (PA5-110812) in IHC (P)
Immunohistochemical analysis of CYP11A1 in human adrenal gland and cerebral cortex tissues using CYP11A1 Polyclonal Antibody (Product # PA5-110812) using Anti-CYP11A1 antibody. Corresponding CYP11A1 RNA-seq data are presented for the same tissues.
Product Details
PA5-110812
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CYP11A1. Recombinant protein control fragment (Product #RP-91064).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RSVLVKGCQT FLSAPREGLG RLRVPTGEGA GISTRSPRPF NEIPSPGDNG WLNLYHFWRE TGTHKVHLHH VQNFQKYGPI YREKLGNVES VYVIDPEDVA LLFKSEGPNP ERFLIPPWVA YHQYYQRPIG VLLKKSAA
Highest antigen sequence indentity to the following orthologs: Rat - 59%, Mouse - 73%.
Target Information
CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under the modulation of cAMP signal. CYP11A1 in steroidogenic cells converts cholesterol to pregnenolone, which is determined by hormonal control of cholesterol availability. Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, and the upstream SF-1 binding site in the CYP11A1 gene is required for hormonal stimulation. c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in the interstitial cell monolayer, which has a fully functional adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cholesterol 20-22 desmolase; Cholesterol desmolase; cholesterol monooxygenase (side-chain cleaving); Cholesterol side-chain cleavage enzyme, mitochondrial; CYPXIA1; Cytochrome P450 11A1; cytochrome P450 family 11 subfamily A polypeptide 1; Cytochrome P450(scc); cytochrome P450, family 11, subfamily A, polypeptide 1; cytochrome P450, subfamily XIA (cholesterol side chain cleavage); cytochrome P450C11A1; steroid 20-22-lyase
Gene Aliases: CYP11A; CYP11A1; CYPXIA1; P450SCC
UniProt ID: (Human) P05108
Entrez Gene ID: (Human) 1583
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process
cholesterol metabolic process
sterol metabolic process
cortisol metabolic process
vitamin D metabolic process
secondary metabolite biosynthetic process
oxidation-reduction process
cellular response to peptide hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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