Search
Invitrogen
CYP11A1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 4
CYP11A1 Antibody (PA5-110812) in IHC (P)
Immunohistochemical analysis of CYP11A1 in human adrenal gland and cerebral cortex tissues using CYP11A1 Polyclonal Antibody (Product # PA5-110812) using Anti-CYP11A1 antibody. Corresponding CYP11A1 RNA-seq data are presented for the same tissues.
Product Details
PA5-110812
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CYP11A1. Recombinant protein control fragment (Product #RP-91064).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RSVLVKGCQT FLSAPREGLG RLRVPTGEGA GISTRSPRPF NEIPSPGDNG WLNLYHFWRE TGTHKVHLHH VQNFQKYGPI YREKLGNVES VYVIDPEDVA LLFKSEGPNP ERFLIPPWVA YHQYYQRPIG VLLKKSAA
Highest antigen sequence indentity to the following orthologs: Rat - 59%, Mouse - 73%.
Target Information
CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under the modulation of cAMP signal. CYP11A1 in steroidogenic cells converts cholesterol to pregnenolone, which is determined by hormonal control of cholesterol availability. Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, and the upstream SF-1 binding site in the CYP11A1 gene is required for hormonal stimulation. c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in the interstitial cell monolayer, which has a fully functional adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: cholesterol 20-22 desmolase; Cholesterol desmolase; cholesterol monooxygenase (side-chain cleaving); cholesterol side-chain cleavage enzyme P450scc (EC 1.14.15.67); Cholesterol side-chain cleavage enzyme, mitochondrial; CYPXIA1; Cytochrome P450 11A1; cytochrome P450 family 11 subfamily A polypeptide 1; Cytochrome P450(scc); cytochrome P450, subfamily XIA (cholesterol side chain cleavage); steroid 20-22-lyase; unnamed protein product
Gene Aliases: CYP11A; CYP11A1; CYPXIA1; P450SCC
UniProt ID: (Human) P05108
Entrez Gene ID: (Human) 1583
monooxygenase activity
iron ion binding
protein binding
cholesterol monooxygenase (side-chain-cleaving) activity
steroid hydroxylase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
heme binding
metal ion binding
alcohol metabolic process
lipid metabolic process
steroid biosynthetic process
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process
steroid metabolic process
cholesterol metabolic process
C21-steroid hormone metabolic process
sterol metabolic process
cortisol metabolic process
vitamin D metabolic process
cellular response to peptide hormone stimulus
steroid hormone biosynthetic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support