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Invitrogen
GLRA1 Polyclonal Antibody
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Product Details
PA5-110813
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human GLRA1. Recombinant protein control fragment (Product #RP-91080).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LLRFRRKRRH HKEDEAGEGR FNFSAYGMGP ACLQAKDGIS VKGANNSNTT NPPPAPSKSP EEMRKLFIQR AKKIDK
Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 95%.
Target Information
GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GLRA; Glra2; glycine receptor; Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; gra1
Gene Aliases: GLRA1; HKPX1; nmf11; oscillator; ot; spasmodic; spd; STHE
UniProt ID: (Human) P23415, (Mouse) Q64018
Entrez Gene ID: (Human) 2741, (Mouse) 14654
protein binding
zinc ion binding
glycine binding
extracellular-glycine-gated chloride channel activity
transmitter-gated ion channel activity
taurine binding
extracellular ligand-gated ion channel activity
chloride channel activity
extracellular-glycine-gated ion channel activity
ligand-gated ion channel
action potential
startle response
regulation of respiratory gaseous exchange by neurological system process
ion transport
chloride transport
muscle contraction
neuropeptide signaling pathway
acrosome reaction
visual perception
adult walking behavior
ion transmembrane transport
regulation of membrane potential
neuromuscular process controlling posture
protein homooligomerization
protein heterooligomerization
negative regulation of transmission of nerve impulse
synaptic transmission, glycinergic
righting reflex
inhibitory postsynaptic potential
cellular response to amino acid stimulus
cellular response to zinc ion
cellular response to ethanol
response to alcohol
chloride transmembrane transport
positive regulation of acrosome reaction
transport
anion transport
chemical synaptic transmission
regulation of respiratory gaseous exchange
neuromuscular process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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