Search
Invitrogen
Angiopoietin 1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 3
Angiopoietin 1 Antibody (PA5-110842) in IHC (P)
Immunohistochemical analysis of Angiopoietin 1 in human seminal vesicle and pancreas tissues using Angiopoietin 1 Polyclonal Antibody (Product # PA5-110842) using Anti-ANGPT1 antibody. Corresponding ANGPT1 RNA-seq data are presented for the same tissues.
Product Details
PA5-110842
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Angiopoietin 1. Recombinant protein control fragment (Product #RP-92310).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EKENLQGLVT RQTYIIQELE KQLNRATTNN SVLQKQQLEL MDTVHNLVNL CTKEGVLLKG GKREEEKPFR
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 90%.
Target Information
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ANG-1; Angiopoietin-1; KIAA0003; ligand for the TIE2 receptor; unnamed protein product
Gene Aliases: AGP1; AGPT; AGPT-1; ANG1; ANGPT1; HAE5; KIAA0003
UniProt ID: (Human) Q15389
Entrez Gene ID: (Human) 284
angiogenesis
blood vessel development
in utero embryonic development
regulation of endothelial cell proliferation
sprouting angiogenesis
positive regulation of receptor internalization
negative regulation of cytokine production involved in immune response
negative regulation of cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
activation of transmembrane receptor protein tyrosine kinase activity
blood coagulation
positive regulation of endothelial cell migration
positive regulation of gene expression
regulation of skeletal muscle satellite cell proliferation
hemopoiesis
cell differentiation
negative regulation of blood coagulation
heparin biosynthetic process
positive regulation of protein ubiquitination
cell-substrate adhesion
regulation of tumor necrosis factor production
protein localization to cell surface
negative regulation of protein import into nucleus
negative regulation of apoptotic process
negative regulation of vascular permeability
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
positive regulation of blood vessel endothelial cell migration
positive regulation of cell adhesion
Tie signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of coagulation
positive chemotaxis
positive regulation of multicellular organismal process
neuron apoptotic process
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
glomerulus vasculature development
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of maintenance of permeability of blood-brain barrier
negative regulation of endothelial cell apoptotic process
regulation of macrophage migration inhibitory factor signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support