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Invitrogen
eIF4E2 Polyclonal Antibody
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Product Details
PA5-110849
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human eIF4E2. Recombinant protein control fragment (Product #RP-89635).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TERDKNQSSS KRKAVVPGPA EHPLQYNYTF WYSRRTPGRP TSSQSYEQNI KQIGTFASVE QFWRFYSHMV RPGDLTGHSD FHLFKEGIKP MWEDDANKNG GKWIIRL
Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 95%.
Target Information
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: eIF-4E type 2; eIF4E-like cap-binding protein; eIF4E-like protein 4E-LP; eukar; Eukaryotic translation initiation factor 4E homologous protein; Eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; h4EHP; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 3; similar to eIF4E; similar to eukaryotic translation initiation factor eIF4E; unnamed protein product
Gene Aliases: 4E-LP; 4EHP; EIF4E2; EIF4EL3; h4EHP; IF4e
UniProt ID: (Human) O60573
Entrez Gene ID: (Human) 9470
translation
translational initiation
regulation of translation
negative regulation of translation
gene silencing by RNA
miRNA mediated inhibition of translation
negative regulation of translational initiation
type I interferon signaling pathway
negative regulation of type I interferon-mediated signaling pathway
rescue of stalled ribosome
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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