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Invitrogen
BRD9 Polyclonal Antibody
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Product Details
PA5-110872
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human BRD9. Recombinant protein control fragment (Product #RP-93569).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MGYLKRNGDG SLLYSVVNTA EPDADEEETH PVDLSSLSSK LLPGFTTLGF KDERRNKVTF LSSATTALSM QNNSVFGDLK SDEMELLYS
Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
The BRD9 gene encodes a protein that is a crucial subunit of the SWI/SNF chromatin remodeling complex known as ncBAF (non-canonical BAF complex). As a bromodomain-containing protein, BRD9 acts as an 'epigenetic reader,' selectively recognizing acetyl-lysine marks on histones, which is essential for regulating chromatin structure and gene expression through the recruitment of acetylated transcriptional regulators. It has emerged as a significant player in epigenetic modulation and has been implicated in various cancers, such as cervical and non-small cell lung cancer, due to its over-expression. BRD9 is situated on the 5p arm of chromosome 5 and is a potential target for anticancer therapies, notably in acute myeloid leukemia (AML). Recent studies highlight the development of selective BRD9 inhibitors, indicating its potential for therapeutic targeting. Its role in cancer is linked to its function in transcriptional regulation and its involvement in the mammalian SWI/SNF complex, which is linked to tumor suppression mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bromodomain-containing protein 9; DKFZp434D0711; DKFZp686L0539; FLJ43530; Rhabdomyosarcoma antigen MU-RMS-40.8; sarcoma antigen NY-SAR-29
Gene Aliases: BRD9; LAVS3040; PRO9856; UNQ3040/PRO9856
UniProt ID: (Human) Q9H8M2
Entrez Gene ID: (Human) 65980
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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