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Invitrogen
DGKD Polyclonal Antibody
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Product Details
PA5-110941
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human DGKD. Recombinant protein control fragment (Product #RP-104581).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TQMDQFGQAA GVLIHSIREI AQSHRDMEQE LAHAVNASSK SMDRVYGKPR TTEGLNCSFV LEMVNNFRAL RSETELLLSG KMALQLDPPQ KEQLGSALAE MDRQLRRLAD TPWLCQSAEP GDEESVMLDL A
Highest antigen sequence indentity to the following orthologs: Mouse - 84%, Rat - 84%.
Target Information
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid are lipids that act as second messengers in signaling cascades. DGK-alpha influences cell activation and secretion of lethal exosomes, which in turn control cell death. DGK-beta is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle. DGK-gamma encodes full-length and truncated transcripts that are present in a range of human tissues, with greatest expression observed in retina. DGK-delta is most abundant in skeletal muscle. DGK-epsilon shows specificity for arachidonylcontaining diacylglycerol and is expressed predominantly in testis. DGK-theta is most abundant in the cerebellum and hippocampus. DGK-iota is present in brain and retina as a predominant transcript of more than 12 kb, including a long 3-prime untranslated region, with additional low abundance transcripts of 9.5 and 7.5 kb. DGK-eta is closely related to DGK-delta. DGK-zeta is most abundant in brain and muscle. DGKs have structural motifs that play regulatory roles, and these motifs form the basis for dividing the DGKs into five subtypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa diacylglycerol kinase; DAG kinase delta; DGK delta; DGK-delta; Diacylglycerol kinase delta; diacylglycerol kinase, delta 130kDa; Diglyceride kinase; Diglyceride kinase delta; EC 2.7.1.107; FLJ26930
Gene Aliases: DGKD; dgkd-2; DGKdelta; KIAA0145
UniProt ID: (Human) Q16760
Entrez Gene ID: (Human) 8527
endocytosis
signal transduction
epidermal growth factor receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
multicellular organism development
response to organic substance
protein transport
cell growth
phosphorylation
second-messenger-mediated signaling
platelet activation
diacylglycerol metabolic process
protein homooligomerization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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