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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: EEPCAESKAM PKSEIPSPQS QLLEDAEANL VGREAAKQQR KELAGGDFTS PDASASSCGK EVPEDSNNFD GSHVYMHSDY NVYRVRSRYN SDWGETGTEQ DEEEDSDENS YYQP
Highest antigen sequence indentity to the following orthologs: Mouse - 80%, Rat - 77%.
Neurabin I is a brain-specific protein which contains an F-actin binding domain, a PDZ domain, a transmembrane-protein-interacting-domain, and a coiled-coil region. As its structure suggests, neurabin I is a promiscuous protein binding to F-actin, protein phosphatase 1, TGN38, and p70 S6 kinase. Found exclusively in brain, this protein is highly concentrated in the synapse and has also been shown to be enriched in the lamellipodia of the growth cone during neuronal development. Neurabin I appears to be a bridging protein by targeting other proteins to the synapse or by linking membrane proteins to the actin cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Neurabin-1; Neurabin-I; Neural tissue-specific F-actin-binding protein I; Protein phosphatase 1 regulatory subunit 9A
Gene Aliases: KIAA1222; PPP1R9A
Entrez Gene ID: (Human) 55607
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