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Invitrogen

Bax Polyclonal Antibody

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Bax Polyclonal Antibody

Product Details

PA5-110949

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human Bax. Recombinant protein control fragment (Product #RP-95261).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2856360

Product Specific Information

Immunogen sequence: GPTSSEQIMK TGALLLQGFI QDRAGRMGGE APELALDPVP QDASTKKLSE CLKRIGDELD SNMELQRMIA AVDTDSPREV FFRVAADMFS DGNFNW

Highest antigen sequence indentity to the following orthologs: Rat - 88%, Mouse - 90%.

Target Information

BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alternatively spliced; Bax zeta; Baxdelta2(G7); Baxdelta2(G8)-RFS protein; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4; BCL2 associated X protein; BCL2-associated X protein omega; bcl2-L-4; unnamed protein product

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Gene Aliases: BCL2L4

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UniProt ID: (Human) Q07812

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Entrez Gene ID: (Human) 581

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Function(s)
protein binding lipid binding channel activity Hsp70 protein binding identical protein binding protein homodimerization activity protein heterodimerization activity chaperone binding BH3 domain binding
Process(es)
B cell apoptotic process release of cytochrome c from mitochondria apoptotic process mitochondrial fusion extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage apoptotic mitochondrial changes response to toxic substance establishment or maintenance of transmembrane electrochemical gradient negative regulation of mitochondrial membrane potential positive regulation of protein complex assembly negative regulation of protein binding endoplasmic reticulum calcium ion homeostasis release of matrix enzymes from mitochondria cellular response to stress cellular response to unfolded protein regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process regulation of neuron apoptotic process positive regulation of neuron apoptotic process mitochondrial fragmentation involved in apoptotic process regulation of mitochondrial membrane potential intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of release of cytochrome c from mitochondria apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand intrinsic apoptotic signaling pathway execution phase of apoptosis fibril organization cellular response to virus positive regulation of apoptotic DNA fragmentation regulation of intracellular signal transduction positive regulation of IRE1-mediated unfolded protein response B cell receptor apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway
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