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Invitrogen
DTNBP1 Polyclonal Antibody
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Product Details
PA5-110983
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human DTNBP1. Recombinant protein control fragment (Product #RP-94608).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LNSGGEENTV LSPALGPESS TCQNEITLQV PNPSELRAKP PSSSSTCTDS ATRDISEGGE SPVVQSDE
Highest antigen sequence indentity to the following orthologs: Rat - 54%, Mouse - 51%.
Target Information
Dtnbp1 may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations are associated with Hermansky-Pudlak syndrome type 7. This protein may also be associated with schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: biogenesis of lysosomal organelles complex-1, subunit 8; Biogenesis of lysosome-related organelles complex 1 subunit 8; BLOC-1 subunit 8; DKFZp564K192; DTBP1; Dysbindin; Dysbindin-1; Dystrobrevin-binding protein 1; FLJ30031; Hermansky-Pudlak syndrome 7 protein; HPS7 protein; Hps7-like protein; MGC20210; OTTHUMP00000221462; OTTHUMP00000221485; RP1-147M19.1; subunit of BLOC-1; unnamed protein product
Gene Aliases: BLOC1S8; DBND; DTNBP1; HPS7; My031; SDY
UniProt ID: (Human) Q96EV8
Entrez Gene ID: (Human) 84062
kidney development
positive regulation of neurotransmitter secretion
positive regulation of receptor internalization
blood coagulation
memory
anterograde axonal transport
regulation of signal transduction
positive regulation of gene expression
regulation of dopamine secretion
actin cytoskeleton organization
neuron projection development
melanosome organization
anterograde synaptic vesicle transport
neuron projection morphogenesis
dendrite morphogenesis
retina development in camera-type eye
platelet dense granule organization
regulation of dopamine receptor signaling pathway
cilium morphogenesis
negative regulation of dendritic spine morphogenesis
positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
protein transmembrane transport
regulation of synaptic vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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