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Invitrogen

BTRC Polyclonal Antibody

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BTRC Polyclonal Antibody

Product Details

PA5-111014

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human BTRC. Recombinant protein control fragment (Product #RP-104626).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.50 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2856425

Product Specific Information

Immunogen sequence: ALKFMNSSER EDCNNGEPPR KIIPEKNSLR QTYNSCARLC LNQETVCLAS TAMKTENCVA KTKLANGTSS MIVPKQRKLS ASYEKEKELC VKYFEQWSES DQVEFVEHLI SQMCHYQHGH

Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 98%.

Target Information

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: beta-transducin repeats-containing protein; beta-TrCP1; E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; F-box and WD-repeat protein 1B; F-box/WD repeat-containing protein 1A; pIkappaBalpha-E3 receptor subunit; unnamed protein product

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Gene Aliases: BETA-TRCP; betaTrCP; BTRC; BTRCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1

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UniProt ID: (Human) Q9Y297

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Entrez Gene ID: (Human) 8945

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Function(s)
protein binding beta-catenin binding ligase activity protein phosphorylated amino acid binding protein dimerization activity ubiquitin protein ligase activity protein binding, bridging involved in substrate recognition for ubiquitination ubiquitin ligase activator activity
Process(es)
autophagosome assembly negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination protein dephosphorylation ubiquitin-dependent protein catabolic process lysosome organization signal transduction negative regulation of autophagy positive regulation of autophagy Wnt signaling pathway protein ubiquitination protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein destabilization cellular response to nutrient levels mammary gland epithelial cell proliferation NIK/NF-kappaB signaling TORC1 signaling regulation of circadian rhythm positive regulation of circadian rhythm regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of proteolysis negative regulation of smoothened signaling pathway positive regulation of transcription, DNA-templated rhythmic process T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway regulation of cell cycle branching involved in mammary gland duct morphogenesis regulation of canonical Wnt signaling pathway regulation of proteasomal protein catabolic process protein K63-linked ubiquitination protein K48-linked ubiquitination negative regulation of TORC1 signaling
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