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Invitrogen
BTRC Polyclonal Antibody
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Product Details
PA5-111014
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human BTRC. Recombinant protein control fragment (Product #RP-104626).
Conjugate
Form
Liquid
Concentration
0.50 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ALKFMNSSER EDCNNGEPPR KIIPEKNSLR QTYNSCARLC LNQETVCLAS TAMKTENCVA KTKLANGTSS MIVPKQRKLS ASYEKEKELC VKYFEQWSES DQVEFVEHLI SQMCHYQHGH
Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 98%.
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-transducin repeats-containing protein; beta-TrCP1; E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; F-box and WD-repeat protein 1B; F-box/WD repeat-containing protein 1A; pIkappaBalpha-E3 receptor subunit; unnamed protein product
Gene Aliases: BETA-TRCP; betaTrCP; BTRC; BTRCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1
UniProt ID: (Human) Q9Y297
Entrez Gene ID: (Human) 8945
autophagosome assembly
negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
protein dephosphorylation
ubiquitin-dependent protein catabolic process
lysosome organization
signal transduction
negative regulation of autophagy
positive regulation of autophagy
Wnt signaling pathway
protein ubiquitination
protein catabolic process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
protein destabilization
cellular response to nutrient levels
mammary gland epithelial cell proliferation
NIK/NF-kappaB signaling
TORC1 signaling
regulation of circadian rhythm
positive regulation of circadian rhythm
regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of proteolysis
negative regulation of smoothened signaling pathway
positive regulation of transcription, DNA-templated
rhythmic process
T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
regulation of cell cycle
branching involved in mammary gland duct morphogenesis
regulation of canonical Wnt signaling pathway
regulation of proteasomal protein catabolic process
protein K63-linked ubiquitination
protein K48-linked ubiquitination
negative regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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