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Invitrogen
CCR7 Polyclonal Antibody
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Product Details
PA5-111020
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CCR7. Recombinant protein control fragment (Product #RP-105854).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GVKFRNDLFK LFKDLGCLSQ EQLRQWSSCR HIRRSSMSVE AETTTTFS
Highest antigen sequence indentity to the following orthologs: Mouse - 83%, Rat - 85%.
Target Information
CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naive from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC's. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BLR2; Bukitt's lymphoma receptor 2; C-C chemokine receptor type 7; C-C CKR-7; CC chemokine receptor 7; CD197; CDw197; chemokine (C-C motif) receptor 7; EBI1; EBV-induced G protein-coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; G-protein coupled receptor; CCR7; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor; unnamed protein product
Gene Aliases: BLR2; CC-CKR-7; CCR-7; CCR7; CD197; CDw197; CMKBR7; EBI1; EVI1
UniProt ID: (Human) P32248
Entrez Gene ID: (Human) 1236
establishment of T cell polarity
positive regulation of cell-matrix adhesion
dendritic cell chemotaxis
myeloid dendritic cell chemotaxis
positive regulation of dendritic cell antigen processing and presentation
positive regulation of hypersensitivity
positive regulation of humoral immune response
chemotaxis
inflammatory response
immune response
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
calcium-mediated signaling
positive regulation of actin filament polymerization
positive regulation of pseudopodium assembly
ruffle organization
regulation of Cdc42 protein signal transduction
response to lipopolysaccharide
regulation of interferon-gamma production
regulation of interleukin-1 beta production
negative regulation of interleukin-12 production
positive regulation of interleukin-12 production
positive regulation of Rac protein signal transduction
CCL19-activated CCR7 signaling pathway
CCL21-activated CCR7 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative thymic T cell selection
positive regulation of cell adhesion
positive regulation of JNK cascade
positive regulation of receptor-mediated endocytosis
homeostasis of number of cells
positive regulation of T cell receptor signaling pathway
release of sequestered calcium ion into cytosol
positive regulation of filopodium assembly
positive regulation of protein kinase B signaling
cell chemotaxis
positive regulation of ERK1 and ERK2 cascade
cellular response to cytokine stimulus
cellular response to prostaglandin E stimulus
response to nitric oxide
positive regulation of neutrophil chemotaxis
lymphocyte migration into lymph node
mature conventional dendritic cell differentiation
positive regulation of phospholipase C/protein kinase C signal transduction
positive regulation of cell motility
positive regulation of dendritic cell chemotaxis
positive regulation of immunological synapse formation
positive regulation of T cell costimulation
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
regulation of dendritic cell dendrite assembly
negative regulation of dendritic cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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