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Invitrogen
P2X7 Polyclonal Antibody
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Product Details
PA5-111049
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human P2X7. Recombinant protein control fragment (Product #RP-94974).
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CRSHIYPWCK CCQPCVVNEY YYRKKCESIV EPKPTLKYVS FVDESHIRMV NQQLLGRSLQ DVKGQEVPRP AMDFTDLSR
Highest antigen sequence indentity to the following orthologs: Mouse - 85%, Rat - 82%.
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7 variant A
Gene Aliases: P2RX7; P2X7
UniProt ID: (Human) Q99572
Entrez Gene ID: (Human) 5027
activation of MAPK activity
cell morphogenesis
phagolysosome assembly
positive regulation of T cell mediated cytotoxicity
regulation of sodium ion transport
protein phosphorylation
membrane protein ectodomain proteolysis
phospholipid transfer to membrane
membrane budding
inflammatory response
mitochondrion organization
cell surface receptor signaling pathway
blood coagulation
response to mechanical stimulus
response to zinc ion
positive regulation of calcium ion transport into cytosol
positive regulation of gene expression
positive regulation of glutamate secretion
positive regulation of gamma-aminobutyric acid secretion
synaptic vesicle exocytosis
protein processing
phospholipid scrambling
sensory perception of pain
cytolysis
positive regulation of bone mineralization
cellular response to extracellular stimulus
bleb assembly
positive regulation of prostaglandin secretion
response to lipopolysaccharide
positive regulation of interleukin-6 production
collagen metabolic process
response to ATP
response to fluid shear stress
positive regulation of ion transmembrane transport
purinergic nucleotide receptor signaling pathway
T cell proliferation
response to drug
T cell homeostasis
NAD transport
negative regulation of MAPK cascade
multicellular organismal protein catabolic process
phospholipid translocation
negative regulation of bone resorption
negative regulation of cell volume
positive regulation of glycolytic process
positive regulation of cytolysis
ceramide biosynthetic process
pore complex assembly
skeletal system morphogenesis
homeostasis of number of cells within a tissue
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
defense response to Gram-positive bacterium
release of sequestered calcium ion into cytosol
protein oligomerization
positive regulation of cytoskeleton organization
response to calcium ion
response to electrical stimulus
regulation of killing of cells of other organism
membrane depolarization
positive regulation of mitochondrial depolarization
positive regulation of lymphocyte apoptotic process
cellular response to dsRNA
reactive oxygen species metabolic process
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
positive regulation of bleb assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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