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Invitrogen
ATP2C1 Polyclonal Antibody
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Product Details
PA5-111052
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human ATP2C1. Recombinant protein control fragment (Product #RP-95777).
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AIASRLGLYS KTSQSVSGEE IDAMDVQQLS QIVPKVAVFY RASPRHKMKI IKSLQKNGSV VAMTGD
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 92%.
Target Information
ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; ATPase, Ca(2+)-sequestering; ATPase, Ca++ transporting, type 2C, member 1; Ca(2+)/Mn(2+)-ATPase 2C1; Calcium-transporting ATPase type 2C member 1; calcium-transporting ATPase type 2C member 1 M; calcium-transporting ATPase type 2C member 1 MU; HUSSY 28; HUSSY-28; rat; Secretory pathway Ca(2+)-transporting ATPase type 1; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA1; SPCA1; ATP2C1b; SPCA1d; ATP2C1d; unnamed protein product
Gene Aliases: ATP2C1; ATP2C1A; BCPM; HHD; hSPCA1; HUSSY-28; KIAA1347; PMR1; PMR1L; SPCA1
UniProt ID: (Human) P98194
Entrez Gene ID: (Human) 27032
ion transport
calcium ion transport
manganese ion transport
cellular calcium ion homeostasis
epidermis development
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cellular manganese ion homeostasis
actin cytoskeleton organization
Golgi calcium ion homeostasis
Golgi calcium ion transport
positive regulation of Golgi to plasma membrane protein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
calcium ion transmembrane transport
manganese ion transmembrane transport
trans-Golgi network membrane organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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