Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

TREX1 Polyclonal Antibody

View all (26) TREX1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
TREX1 Polyclonal Antibody

Product Details

PA5-111063

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human TREX1. Recombinant protein control fragment (Product #RP-96493).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2856474

Product Specific Information

Immunogen sequence: PPPTVPPPPR VVDKLSLCVA PGKACSPAAS EITGLSTAVL AAHGRQCFDD NLANLLLAFL RRQPQPWCLV AHNGDRYD

Highest antigen sequence indentity to the following orthologs: Rat - 78%, Mouse - 81%.

Target Information

Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: 3' repair exonuclease 1; 3'-5' exonuclease TREX1; Deoxyribonuclease III; DNase III; Three-prime repair exonuclease 1; TREX1; unnamed protein product

View more View less

Gene Aliases: AGS1; CRV; DRN3; HERNS; RVCLS; TREX1

View more View less

UniProt ID: (Human) Q9NSU2

View more View less

Entrez Gene ID: (Human) 11277

View more View less

Function(s)
magnesium ion binding nucleic acid binding DNA binding double-stranded DNA binding single-stranded DNA binding nuclease activity exonuclease activity exodeoxyribonuclease activity protein binding 3'-5'-exodeoxyribonuclease activity DNA binding, bending double-stranded DNA 3'-5' exodeoxyribonuclease activity 3'-5' exonuclease activity hydrolase activity MutLalpha complex binding MutSalpha complex binding adenyl deoxyribonucleotide binding identical protein binding protein homodimerization activity metal ion binding WW domain binding
Process(es)
DNA damage checkpoint blood vessel development kidney development adaptive immune response organ or tissue specific immune response activation of immune response macrophage activation involved in immune response lymphoid progenitor cell differentiation immune response in brain or nervous system inflammatory response to antigenic stimulus T cell antigen processing and presentation regulation of immunoglobulin production heart morphogenesis heart process atrial cardiac muscle tissue development generation of precursor metabolites and energy regulation of glycolytic process DNA metabolic process DNA replication DNA repair mismatch repair DNA modification DNA catabolic process DNA recombination inflammatory response immune response cellular response to DNA damage stimulus determination of adult lifespan response to UV regulation of gene expression regulation of fatty acid metabolic process regulation of metabolic process mitotic G1 DNA damage checkpoint transposition, RNA-mediated regulation of type I interferon production regulation of tumor necrosis factor production cellular response to oxidative stress cellular response to reactive oxygen species cellular response to UV cellular response to interferon-beta apoptotic cell clearance regulation of cellular respiration innate immune response regulation of innate immune response establishment of protein localization negative regulation of innate immune response regulation of lipid biosynthetic process regulation of inflammatory response protein stabilization regulation of T cell activation defense response to virus type I interferon signaling pathway negative regulation of type I interferon-mediated signaling pathway regulation of protein complex stability cellular response to type I interferon cellular response to gamma radiation cellular response to hydroxyurea immune complex formation cGAS/STING signaling pathway negative regulation of cGAS/STING signaling pathway DNA synthesis involved in UV-damage excision repair regulation of lysosome organization
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support